Ekspozycja na pepsynę w środowisku niekwaśnym zwiększa ekspresję mucyny 5AC (MUC5AC) poprzez metaloproteinazę macierzy 9 (MMP9)/czynnik jądrowy κB (NF-κB) w ludzkich komórkach nabłonka dróg oddechowych
Refluks żołądkowy (GR) to cofanie się treści żołądkowej do przewodu pokarmowego. Wcześniej stwierdzono, że GR jest związany z chorobami zapalnymi dróg oddechowych i potencjalną przyczyną przebudowy dróg oddechowych. Przewlekła ekspozycja na treść żołądkową może powodować uszkodzenia od nosa do płuc, ponieważ enzymy trawienne i kwasowość są toksyczne dla komórek nabłonka dróg oddechowych.
Ostatnio stwierdzono, że toksyczność pepsyny w środowisku niekwaśnym zwiększa prozapalne cytokiny i receptory w nabłonku przewodu pokarmowego. Jednak wpływ pepsyny w warunkach bezkwasowych na ekspresję mucyny nie był badany w ludzkich komórkach nabłonka dróg oddechowych. Celem tego badania była ocena wpływu pepsyny na ekspresję mucyny 5AC (MUC5AC) w komórkach nabłonka górnych i dolnych dróg oddechowych jako ważnego potencjalnego czynnika niekwaśnego zapalenia dróg oddechowych związanego z GR.
Walidacja w Chinach nieinwazyjnego biomarkera pepsyny ślinowej zawierającego dwa unikalne przeciwciała monoklonalne dla ludzkiej pepsyny do diagnozowania choroby refluksowej przełyku.

Białko szoku cieplnego 70 jest indukowane przez pepsynę za pośrednictwem sygnalizacji MAPK w ludzkich komórkach nabłonka nosa
Spontaniczna , katalizowana pepsyną C aktywacja ludzkiego pepsynogenu C w hodowli zawiesinowej transgenicznych komórek ryżu: Produkcja i charakterystyka ludzkiej pepsyny C.
Pepsin ELISA Kit| Rat Pepsin ELISA Kit |
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EF017993 | Lifescience Market | 96 Tests | 826.8 EUR |
Human Pepsin ELISA kit |
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E01P0699-192T | BlueGene | 192 tests | 1524 EUR |
Human Pepsin ELISA kit |
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E01P0699-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Human Pepsin ELISA kit |
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E01P0699-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Human Pepsin ELISA Kit |
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CN-03533H1 | ChemNorm | 96T | 561.6 EUR |
Human Pepsin ELISA Kit |
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CN-03533H2 | ChemNorm | 48T | 386.4 EUR |
Human Pepsin ELISA Kit |
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20-abx152697 | Abbexa |
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Human Pepsin ELISA Kit |
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abx253017-96tests | Abbexa | 96 tests | 801.6 EUR |
Human Pepsin ELISA Kit |
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20-abx258448 | Abbexa |
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Human Pepsin (PP) ELISA Kit |
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CEA632Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | 5402.92 EUR |
Human Pepsin (PP) ELISA Kit |
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CEA632Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | 550.13 EUR |
Human Pepsin (PP) ELISA Kit |
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CEA632Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | 734.46 EUR |
Human Pepsin (PP) ELISA Kit |
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CEA632Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | 2945.08 EUR |
Human Pepsin (PP) ELISA Kit |
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4-CEA632Hu | Cloud-Clone |
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Human Pepsin, PG ELISA Kit |
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CSB-E08919h-24T | Cusabio | 1 plate of 24 wells | 198 EUR |
Human Pepsin, PG ELISA Kit |
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1-CSB-E08919h | Cusabio |
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Human PP(Pepsin) ELISA Kit |
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EH3629 | FN Test | 96T | 628.92 EUR |
Human Pepsin A ELISA Kit |
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abx253940-96tests | Abbexa | 96 tests | 764.4 EUR |
Human Pepsin,PP ELISA Kit |
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201-12-0923 | SunredBio | 96 tests | 528 EUR |
Human Pepsin(PP)ELISA Kit |
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GA-E0939HM-48T | GenAsia Biotech | 48T | 346.8 EUR |
Human Pepsin(PP)ELISA Kit |
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GA-E0939HM-96T | GenAsia Biotech | 96T | 559.2 EUR |
Human Pepsin(PP)ELISA Kit |
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QY-E01049 | Qayee Biotechnology | 96T | 433.2 EUR |
Human Pepsin (PP) ELISA Kit |
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SEA632Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | 5677.8 EUR |
Human Pepsin (PP) ELISA Kit |
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SEA632Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | 572.76 EUR |
Human Pepsin (PP) ELISA Kit |
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SEA632Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | 766.8 EUR |
Human Pepsin (PP) ELISA Kit |
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SEA632Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | 3090.6 EUR |
Human Pepsin (PP) ELISA Kit |
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4-SEA632Hu | Cloud-Clone |
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Human Pepsin ELISA Kit (PP) |
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RK02117 | Abclonal | 96 Tests | 625.2 EUR |
Human Pepsin,PP ELISA Kit |
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YLA1674HU-48T | Shanghai YL Biotech | 48T | 435 EUR |
Human Pepsin,PP ELISA Kit |
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YLA1674HU-96T | Shanghai YL Biotech | 96T | 562.5 EUR |
Rat Pepsin ELISA Kit |
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CN-01695R1 | ChemNorm | 96T | 548.4 EUR |
Rat Pepsin ELISA Kit |
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CN-01695R2 | ChemNorm | 48T | 367.2 EUR |
Mouse Pepsin ELISA Kit |
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CN-02572M1 | ChemNorm | 96T | 536.4 EUR |
Mouse Pepsin ELISA Kit |
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CN-02572M2 | ChemNorm | 48T | 355.2 EUR |
Goat Pepsin ELISA kit |
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E06P0699-192T | BlueGene | 192 tests | 1524 EUR |
Goat Pepsin ELISA kit |
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E06P0699-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Goat Pepsin ELISA kit |
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E06P0699-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Dog Pepsin ELISA kit |
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E08P0699-192T | BlueGene | 192 tests | 1524 EUR |
Dog Pepsin ELISA kit |
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E08P0699-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Dog Pepsin ELISA kit |
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E08P0699-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Rabbit Pepsin ELISA kit |
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E04P0699-192T | BlueGene | 192 tests | 1524 EUR |
Rabbit Pepsin ELISA kit |
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E04P0699-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Rabbit Pepsin ELISA kit |
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E04P0699-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Pig Pepsin ELISA kit |
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E07P0699-192T | BlueGene | 192 tests | 1524 EUR |
Pig Pepsin ELISA kit |
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E07P0699-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Pig Pepsin ELISA kit |
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E07P0699-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Mouse Pepsin ELISA kit |
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E03P0699-192T | BlueGene | 192 tests | 1524 EUR |
Mouse Pepsin ELISA kit |
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E03P0699-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Mouse Pepsin ELISA kit |
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E03P0699-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Rat Pepsin ELISA kit |
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E02P0699-192T | BlueGene | 192 tests | 1524 EUR |
Rat Pepsin ELISA kit |
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E02P0699-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Rat Pepsin ELISA kit |
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E02P0699-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Chicken Pepsin ELISA Kit |
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abx354711-96tests | Abbexa | 96 tests | 990 EUR |
Monkey Pepsin ELISA Kit |
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abx354985-96tests | Abbexa | 96 tests | 990 EUR |
Rabbit Pepsin ELISA Kit |
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abx355279-96tests | Abbexa | 96 tests | 990 EUR |
Mouse Pepsin ELISA Kit |
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abx254361-96tests | Abbexa | 96 tests | 801.6 EUR |
Rat Pepsin ELISA Kit |
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abx255946-96tests | Abbexa | 96 tests | 801.6 EUR |
Mouse Pepsin ELISA Kit |
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20-abx258284 | Abbexa |
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Rat Pepsin ELISA Kit |
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20-abx258285 | Abbexa |
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Pig Pepsin ELISA Kit |
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abx255552-96tests | Abbexa | 96 tests | 943.2 EUR |
Monkey Pepsin ELISA kit |
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E09P0699-192T | BlueGene | 192 tests | 1524 EUR |
Monkey Pepsin ELISA kit |
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E09P0699-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Monkey Pepsin ELISA kit |
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E09P0699-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
ELISA kit for Human PP (Pepsin) |
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E-EL-H2050 | Elabscience Biotech | 1 plate of 96 wells | 640.8 EUR |
Human PGA/ Pepsin A ELISA Kit |
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E1914Hu | Sunlong | 1 Kit | 685.2 EUR |
Human Pepsin A-3 ELISA Kit |
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abx513566-96tests | Abbexa | 96 tests | 801.6 EUR |
ELISA kit for Human Pepsin (PG) |
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KTE61240-48T | Abbkine | 48T | 424.8 EUR |
ELISA kit for Human Pepsin (PG) |
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KTE61240-5platesof96wells | Abbkine | 5 plates of 96 wells | 2702.4 EUR |
ELISA kit for Human Pepsin (PG) |
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KTE61240-96T | Abbkine | 96T | 686.4 EUR |
Human PGA3(Pepsin A) ELISA Kit |
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EH0985 | FN Test | 96T | 628.92 EUR |
Human Pepsin A, PGA3 ELISA Kit |
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ELI-02244h | Lifescience Market | 96 Tests | 988.8 EUR |
Pepsin |
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abx082440-25g | Abbexa | 25 g | 226.8 EUR |
Pepsin |
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GE5559-100G | Glentham Life Sciences | 100 g | 189.6 EUR |
Pepsin |
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GE5559-25G | Glentham Life Sciences | 25 g | 93.6 EUR |
Pepsin |
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GE5559-5G | Glentham Life Sciences | 5 g | 64.8 EUR |
Pepsin Assay Kit |
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abx298847-100Assays | Abbexa | 100 Assays | 510 EUR |
Mouse Pepsin (PP) ELISA Kit |
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CEA632Mu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | 5552.14 EUR |
Mouse Pepsin (PP) ELISA Kit |
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CEA632Mu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | 562.42 EUR |
Mouse Pepsin (PP) ELISA Kit |
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CEA632Mu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | 752.02 EUR |
Mouse Pepsin (PP) ELISA Kit |
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CEA632Mu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | 3024.07 EUR |
Mouse Pepsin (PP) ELISA Kit |
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4-CEA632Mu | Cloud-Clone |
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Rat Pepsin (PP) ELISA Kit |
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CEA632Ra-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | 5552.14 EUR |
Rat Pepsin (PP) ELISA Kit |
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CEA632Ra-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | 562.42 EUR |
Rat Pepsin (PP) ELISA Kit |
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CEA632Ra-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | 752.02 EUR |
Rat Pepsin (PP) ELISA Kit |
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CEA632Ra-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | 3024.07 EUR |
Rat Pepsin (PP) ELISA Kit |
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4-CEA632Ra | Cloud-Clone |
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Rat Pepsin, PG ELISA Kit |
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CSB-E08920r-24T | Cusabio | 1 plate of 24 wells | 198 EUR |
Rat Pepsin, PG ELISA Kit |
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1-CSB-E08920r | Cusabio |
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Mouse Pepsin, PG ELISA Kit |
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CSB-E08921m-24T | Cusabio | 1 plate of 24 wells | 198 EUR |
Mouse Pepsin, PG ELISA Kit |
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1-CSB-E08921m | Cusabio |
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Guinea pig Pepsin ELISA kit |
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E05P0699-192T | BlueGene | 192 tests | 1524 EUR |
Guinea pig Pepsin ELISA kit |
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E05P0699-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Guinea pig Pepsin ELISA kit |
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E05P0699-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Mouse PP(Pepsin) ELISA Kit |
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EM1304 | FN Test | 96T | 628.92 EUR |
Porcine PP(Pepsin) ELISA Kit |
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EP0138 | FN Test | 96T | 681.12 EUR |
Chicken Pepsin A ELISA Kit |
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abx513564-96tests | Abbexa | 96 tests | 1093.2 EUR |
Dog Pepsin A ELISA Kit |
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abx513565-96tests | Abbexa | 96 tests | 1093.2 EUR |
Pig Pepsin A ELISA Kit |
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abx513568-96tests | Abbexa | 96 tests | 1093.2 EUR |
Rat Pepsin, PP ELISA Kit |
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ELA-E0632r | Lifescience Market | 96 Tests | 1063.2 EUR |
Rat Pepsin(PP)ELISA Kit |
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GA-E0628RT-48T | GenAsia Biotech | 48T | 380.4 EUR |