Ekspozycja na pepsynę w środowisku niekwaśnym zwiększa ekspresję mucyny 5AC (MUC5AC) poprzez metaloproteinazę macierzy 9 (MMP9)/czynnik jądrowy κB (NF-κB) w ludzkich komórkach nabłonka dróg oddechowych
Refluks żołądkowy (GR) to cofanie się treści żołądkowej do przewodu pokarmowego. Wcześniej stwierdzono, że GR jest związany z chorobami zapalnymi dróg oddechowych i potencjalną przyczyną przebudowy dróg oddechowych. Przewlekła ekspozycja na treść żołądkową może powodować uszkodzenia od nosa do płuc, ponieważ enzymy trawienne i kwasowość są toksyczne dla komórek nabłonka dróg oddechowych.
Ostatnio stwierdzono, że toksyczność pepsyny w środowisku niekwaśnym zwiększa prozapalne cytokiny i receptory w nabłonku przewodu pokarmowego. Jednak wpływ pepsyny w warunkach bezkwasowych na ekspresję mucyny nie był badany w ludzkich komórkach nabłonka dróg oddechowych. Celem tego badania była ocena wpływu pepsyny na ekspresję mucyny 5AC (MUC5AC) w komórkach nabłonka górnych i dolnych dróg oddechowych jako ważnego potencjalnego czynnika niekwaśnego zapalenia dróg oddechowych związanego z GR.
Walidacja w Chinach nieinwazyjnego biomarkera pepsyny ślinowej zawierającego dwa unikalne przeciwciała monoklonalne dla ludzkiej pepsyny do diagnozowania choroby refluksowej przełyku.

Białko szoku cieplnego 70 jest indukowane przez pepsynę za pośrednictwem sygnalizacji MAPK w ludzkich komórkach nabłonka nosa
Spontaniczna , katalizowana pepsyną C aktywacja ludzkiego pepsynogenu C w hodowli zawiesinowej transgenicznych komórek ryżu: Produkcja i charakterystyka ludzkiej pepsyny C.
Human Pepsin ELISA Kit |
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20-abx258448 | Abbexa |
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Human Pepsin ELISA Kit |
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abx253017-96tests | Abbexa | 96 tests | 801.6 EUR |
Human Pepsin ELISA Kit |
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CN-03533H1 | ChemNorm | 96T | 561.6 EUR |
Human Pepsin ELISA Kit |
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CN-03533H2 | ChemNorm | 48T | 386.4 EUR |
Human Pepsin ELISA Kit |
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20-abx152697 | Abbexa |
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Human Pepsin ELISA kit |
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E01P0699-192T | BlueGene | 192 tests | 1524 EUR |
Human Pepsin ELISA kit |
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E01P0699-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Human Pepsin ELISA kit |
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E01P0699-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Pepsin ELISA Kit| Rat Pepsin ELISA Kit |
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EF017993 | Lifescience Market | 96 Tests | 826.8 EUR |
Rat Pepsin(Pepsin) ELISA Kit |
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E39ER1281 | EnoGene | 96T | 595 EUR |
Human Pepsin A ELISA Kit |
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abx253940-96tests | Abbexa | 96 tests | 764.4 EUR |
Human Pepsin,PP ELISA Kit |
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201-12-0923 | SunredBio | 96 tests | 528 EUR |
Human Pepsin (PP) ELISA Kit |
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CEA632Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | 5402.92 EUR |
Human Pepsin (PP) ELISA Kit |
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CEA632Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | 550.13 EUR |
Human Pepsin (PP) ELISA Kit |
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CEA632Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | 734.46 EUR |
Human Pepsin (PP) ELISA Kit |
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CEA632Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | 2945.08 EUR |
Human Pepsin (PP) ELISA Kit |
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4-CEA632Hu | Cloud-Clone |
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Human Pepsin, PG ELISA Kit |
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CSB-E08919h-24T | Cusabio | 1 plate of 24 wells | 198 EUR |
Human Pepsin, PG ELISA Kit |
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1-CSB-E08919h | Cusabio |
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Human Pepsin(PP)ELISA Kit |
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GA-E0939HM-48T | GenAsia Biotech | 48T | 346.8 EUR |
Human Pepsin(PP)ELISA Kit |
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GA-E0939HM-96T | GenAsia Biotech | 96T | 559.2 EUR |
Human PP(Pepsin) ELISA Kit |
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EH3629 | FN Test | 96T | 628.92 EUR |
Human Pepsin ELISA Kit (PP) |
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RK02117 | Abclonal | 96 Tests | 625.2 EUR |
Human Pepsin(PP)ELISA Kit |
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QY-E01049 | Qayee Biotechnology | 96T | 433.2 EUR |
Human Pepsin,PP ELISA Kit |
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YLA1674HU-48T | Shanghai YL Biotech | 48T | 435 EUR |
Human Pepsin,PP ELISA Kit |
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YLA1674HU-96T | Shanghai YL Biotech | 96T | 562.5 EUR |
Human Pepsin (PP) ELISA Kit |
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SEA632Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | 5677.8 EUR |
Human Pepsin (PP) ELISA Kit |
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SEA632Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | 572.76 EUR |
Human Pepsin (PP) ELISA Kit |
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SEA632Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | 766.8 EUR |
Human Pepsin (PP) ELISA Kit |
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SEA632Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | 3090.6 EUR |
Human Pepsin (PP) ELISA Kit |
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4-SEA632Hu | Cloud-Clone |
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Human Pepsin (PG) ELISA Kit |
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KTE61240-96T5 | Abbkine | 96 T×5 | 2809 EUR |
Human Pepsin (PG) ELISA Kit |
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KTE61240-96T50 | Abbkine | 96 T×50 | 26209 EUR |
Human Pepsin,PG ELISA Kit |
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EKC34940-48T | Biomatik Corporation | 48T | 597.24 EUR |
Human Pepsin,PG ELISA Kit |
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EKC34940-5x96T | Biomatik Corporation | 5x96T | 4052.7 EUR |
Human Pepsin,PG ELISA Kit |
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EKC34940-96T | Biomatik Corporation | 96T | 853.2 EUR |
Human PP (Pepsin) ELISA Kit |
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EKE61151-5x96T | Biomatik Corporation | 5x96T | 3124.08 EUR |
Human PP (Pepsin) ELISA Kit |
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EKE61151-96T | Biomatik Corporation | 96T | 657.7 EUR |
Human Pepsin,PP ELISA Kit |
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SL1348Hu | Sunlong | 96 Tests | 468 EUR |
Human Pepsin (PP) ELISA Kit |
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EKN51304-48T | Biomatik Corporation | 48T | 345.73 EUR |
Human Pepsin (PP) ELISA Kit |
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EKN51304-5x96T | Biomatik Corporation | 5x96T | 2346.03 EUR |
Human Pepsin (PP) ELISA Kit |
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EKN51304-96T | Biomatik Corporation | 96T | 493.9 EUR |
Human Pepsin (PP) ELISA Kit |
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EKU08576-48T | Biomatik Corporation | 48T | 527.66 EUR |
Human Pepsin (PP) ELISA Kit |
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EKU08576-5x96T | Biomatik Corporation | 5x96T | 3580.55 EUR |
Human Pepsin (PP) ELISA Kit |
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EKU08576-96T | Biomatik Corporation | 96T | 753.8 EUR |
Human Pepsin (PP) ELISA Kit |
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EKU11601-48T | Biomatik Corporation | 48T | 610.82 EUR |
Human Pepsin (PP) ELISA Kit |
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EKU11601-5x96T | Biomatik Corporation | 5x96T | 4144.85 EUR |
Human Pepsin (PP) ELISA Kit |
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EKU11601-96T | Biomatik Corporation | 96T | 872.6 EUR |
Human Pepsin (PP) ELISA Kit |
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EKN49687-48T | Biomatik Corporation | 48T | 328.44 EUR |
Human Pepsin (PP) ELISA Kit |
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EKN49687-5x96T | Biomatik Corporation | 5x96T | 2228.7 EUR |
Human Pepsin (PP) ELISA Kit |
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EKN49687-96T | Biomatik Corporation | 96T | 469.2 EUR |
Human PP(Pepsin) ELISA Kit |
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EKF57694-48T | Biomatik Corporation | 48T | 396.9 EUR |
Human PP(Pepsin) ELISA Kit |
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EKF57694-5x96T | Biomatik Corporation | 5x96T | 2693.25 EUR |
Human PP(Pepsin) ELISA Kit |
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EKF57694-96T | Biomatik Corporation | 96T | 567 EUR |
Human Pepsin (PP) ELISA Kit |
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EKN52712-48T | Biomatik Corporation | 48T | 380.31 EUR |
Human Pepsin (PP) ELISA Kit |
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EKN52712-5x96T | Biomatik Corporation | 5x96T | 2580.68 EUR |
Human Pepsin (PP) ELISA Kit |
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EKN52712-96T | Biomatik Corporation | 96T | 543.3 EUR |
Human Pepsin (PP) ELISA Kit |
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EKU10193-48T | Biomatik Corporation | 48T | 555.66 EUR |
Human Pepsin (PP) ELISA Kit |
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EKU10193-5x96T | Biomatik Corporation | 5x96T | 3770.55 EUR |
Human Pepsin (PP) ELISA Kit |
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EKU10193-96T | Biomatik Corporation | 96T | 793.8 EUR |
Human Pepsin(PP)ELISA Kit |
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NSL1752Hu | Sunlong | 96 wells | 468 EUR |
Human PP(Pepsin) ELISA Kit |
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ELK8433-48T | ELK Biotech | 48T | Ask for price |
Human PP(Pepsin) ELISA Kit |
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ELK8433-96T | ELK Biotech | 96T | Ask for price |
Human Pepsin A-3 ELISA Kit |
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abx513566-96tests | Abbexa | 96 tests | 801.6 EUR |
Human PGA/ Pepsin A ELISA Kit |
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E1914Hu | Sunlong | 1 Kit | 685.2 EUR |
Human PGA3(Pepsin A) ELISA Kit |
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EH0985 | FN Test | 96T | 628.92 EUR |
Human PGA3(Pepsin A) ELISA Kit |
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EKF57271-48T | Biomatik Corporation | 48T | 396.9 EUR |
Human PGA3(Pepsin A) ELISA Kit |
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EKF57271-5x96T | Biomatik Corporation | 5x96T | 2693.25 EUR |
Human PGA3(Pepsin A) ELISA Kit |
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EKF57271-96T | Biomatik Corporation | 96T | 567 EUR |
Human Pepsin A-3 ELISA Kit(PGA3) |
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RK04193 | Abclonal | 96T | 280 EUR |
Human PGA3/ Pepsin A-3 ELISA Kit |
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E1915Hu | Sunlong | 1 Kit | 726 EUR |
ELISA kit for Human PP (Pepsin) |
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E-EL-H2050 | Elabscience Biotech | 1 plate of 96 wells | 640.8 EUR |
ELISA kit for Human Pepsin (PG) |
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KTE61240-48T | Abbkine | 48T | 424.8 EUR |
ELISA kit for Human Pepsin (PG) |
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KTE61240-5platesof96wells | Abbkine | 5 plates of 96 wells | 2702.4 EUR |
ELISA kit for Human Pepsin (PG) |
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KTE61240-96T | Abbkine | 96T | 686.4 EUR |
Human Pepsin A, PGA3 ELISA Kit |
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ELI-02244h | Lifescience Market | 96 Tests | 988.8 EUR |
Rat Pepsin ELISA Kit |
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20-abx258285 | Abbexa |
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Pig Pepsin ELISA Kit |
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abx255552-96tests | Abbexa | 96 tests | 943.2 EUR |
Rat Pepsin ELISA Kit |
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abx255946-96tests | Abbexa | 96 tests | 801.6 EUR |
Rat Pepsin ELISA Kit |
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CN-01695R1 | ChemNorm | 96T | 548.4 EUR |
Rat Pepsin ELISA Kit |
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CN-01695R2 | ChemNorm | 48T | 367.2 EUR |
Rat Pepsin ELISA kit |
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E02P0699-192T | BlueGene | 192 tests | 1524 EUR |
Rat Pepsin ELISA kit |
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E02P0699-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Rat Pepsin ELISA kit |
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E02P0699-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Dog Pepsin ELISA kit |
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E08P0699-192T | BlueGene | 192 tests | 1524 EUR |
Dog Pepsin ELISA kit |
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E08P0699-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Dog Pepsin ELISA kit |
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E08P0699-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Pig Pepsin ELISA kit |
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E07P0699-192T | BlueGene | 192 tests | 1524 EUR |
Pig Pepsin ELISA kit |
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E07P0699-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Pig Pepsin ELISA kit |
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E07P0699-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Rat Pepsin ELISA Kit |
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NSL0264r | Sunlong | 96 Tests | 498 EUR |
Goat Pepsin ELISA kit |
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E06P0699-192T | BlueGene | 192 tests | 1524 EUR |
Goat Pepsin ELISA kit |
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E06P0699-48 | BlueGene | 1 plate of 48 wells | 624 EUR |
Goat Pepsin ELISA kit |
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E06P0699-96 | BlueGene | 1 plate of 96 wells | 822 EUR |
Mouse Pepsin ELISA Kit |
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20-abx258284 | Abbexa |
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Mouse Pepsin ELISA Kit |
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abx254361-96tests | Abbexa | 96 tests | 801.6 EUR |
Mouse Pepsin ELISA Kit |
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CN-02572M1 | ChemNorm | 96T | 536.4 EUR |
Mouse Pepsin ELISA Kit |
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CN-02572M2 | ChemNorm | 48T | 355.2 EUR |
Mouse Pepsin ELISA kit |
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E03P0699-192T | BlueGene | 192 tests | 1524 EUR |
Mouse Pepsin ELISA kit |
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E03P0699-48 | BlueGene | 1 plate of 48 wells | 624 EUR |