Targeting the RNA-Binding Protein HuR Alleviates Neuroinflammation in Experimental Autoimmune Encephalomyelitis: Potential Therapy for Multiple Sclerosis

Multiple sclerosis (MS) is an inflammatory disease and chronic autoimmune neurodegenerative central nervous system characterized by demyelination, axonal loss and motor dysfunction. activated microglia associated with the destruction of myelin in the CNS.

activated microglia produce proinflammatory cytokines and factors, supports nerve inflammation, damage to myelin and neuronal loss, and suspected to be involved in the pathogenesis of the disease.

This study investigated the role of post-transcriptional regulation of gene expression in nerve inflammation associated with experimental autoimmune encephalomyelitis (EAE) in mice, by focusing on Hur, the RNA binding protein is involved in inflammatory and immune phenomena.

part of the spinal cord of EAE mice showed increased Hur abundant immunostaining was detected in the cytoplasm of activated microglia, the patterns associated with increased activity.

Intrathecal administration of anti-Hur antisense oligonucleotide (ASO) reduces the proinflammatory activated microglia inflammatory infiltrates and expression of proinflammatory cytokines IL-1β, TNF-α, and IL-17 and inhibits the activation of NF-kB road. The beneficial effects of anti-Hur ASO in EAE mice is also related to decreased permeability of the blood-brain barrier.

EAE mice showed decrease spinal CD206 immunostaining restored by anti-Hur ASO, showed that silencing Hur promote a shift to the anti-inflammatory and regenerative microglia phenotype. Mice that received anti-Hur related EAE ASO exhibited improved motor dysfunction, pain hypersensitivity, and body weight loss. Hur is targeting may represent an innovative and promising perspectives for the control of neurological disorders in patients with MS.

A Probe Two Armed for In-Cell Measurements DEER Proteins

Double application of electrons resonance (DEER) with site-directed spin labeling (SDSL) to measure the distances of proteins and protein complexes in living cells put tight restrictions on the spin-label.

Linkage and paramagnetic centers need to hold the cell reducing conditions. rigid attachment protein probes for improved accuracy of the measured distance. Here, three two-armed GdIII complex, GdIII -CLaNP13a / b / c synthesized.

Molecular disulfide relations than most other CLaNP, thioether linkage is used to avoid splitting reductive linker. The double GdIII labeled N55C / V57C / K147C / T151C variant of T4Lysozyme measured at 95 GHz STAG. Construction was measured in vitro, in cell lysates and Dictyostelium discoideum cells. the measured distance is 4.5 nm, consistent with the results of NMR paramagnetic.

A narrow distribution range and a typical modulation depth, also in cells, indicating a complete and durable label and the probe rigidity for multiple attachment sites.

SARS-CoV nucleocapsid protein-2 phase-separating the RNA and human hnRNPs

tightly-packed complex nucleocapsid protein and genomic RNA forms the core of the virus and assemble into virus factories, dynamic compartment formed in host cells associated with human stress granules.

Here, we examine the possibility that the multivalent RNA-binding nucleocapsid protein (N) on acute respiratory syndrome coronavirus 2 (SARS-CoV-2) condenses with RNA through the separation of liquid-liquid phase (LLPs), and that the N protein can be recruited in the form of phase is separated from the RNA-binding protein in humans associated with the formation of the SG.

LLPs strongly with RNA requires regular two-intrinsic region (IDRs), N-terminal S and the center-linker S, as well as C-terminal oligomerization domain is folded; while folded N-terminal domain and the C-terminal Rp that are not needed. N phase separation of proteins induced by the addition of non-specific RNA.

In addition, N partitioning in vitro to form separated phases of full-length human hnRNPs (TDP-43, FUS, hnRNPA2) and their lower domain complexity (LC). These results provide a potential mechanism for the role in the SARS-CoV N-2 virus genome in the host packing and co-protein required for viral replication and infectivity.

Acetylation / deacetylation and microtubule associated protein affects the stability and motility of sperm flagellar axonemal

PTM and MAPS is known to regulate microtubule dynamicity in somatic cells. Reported literature on α tubulin modulation acetyl transferase (αTAT1) and Histone Deacetylase 6 (HDAC6) in animal models and cell lines illustrates the differences in tubulin acetylation status associated with stability MT.

Our previous studies showed a decrease in sperm individual tubulin acetyl asthenozoospermic. Our study in mice sperm showed that the inhibition of HDAC6 activity despite increased tubulin acetylation, reduced sperm motility.

The study was therefore conducted to investigate the effect of tubulin acetylation / deacetylation in MT dynamicity in sperm flagella using rat and human sperm. Our data on mice revealed that sperm particular HDAC6 inhibitor Tubastatin A (T) inhibited sperm motility and neutralize the effects of debilitating Nocodazole depolymerizing and motility.

The effect on the polymerization was further confirmed in vitro using pure MT and recHDAC6. Also axoneme polymerized lacking in sperm from asthenozoosperm compared with normozoosperm.

Deacetylase Activity decreased in lysates sperm- and axonemes exposed T and N + T but not in sperm axonemes treated equally show that HDAC6 is associated with sperm axonemes or MT. Deacetylase Activity lacking in asthenozoosperm.

Interestingly, the expression of HDAC6 MDP3 physiologically known to bind to and inhibit its deacetylase activity, remained unchanged. However, the expression of acetyl-α tubulin, HDAC6 and stabilize microtubule protein lacking in asthenozoosperm SAXO1.

Nuclear Pore Complex Proteins/Nup107 Polyclonal Antibody Bio Conjugated
MBS9462636-01mL	MyBiosource	0.1mL	EUR 595

Nuclear Pore Complex Proteins/Nup107 Polyclonal Antibody Bio Conjugated
MBS9462636-5x01mL	MyBiosource	5x0.1mL	EUR 2525

Nuclear pore complex protein Nup153 Antibody
abx109340-100l	Abbexa	100 µl	EUR 162.5

Nuclear pore complex protein Nup153 Antibody
20-abx109340	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	20 ug 50 ug 100 ug 200 ug 1 mg

Nuclear pore complex protein Nup93 (dye) Antibody
abx346920-100l	Abbexa	100 µl	EUR 250

Nuclear pore complex protein Nup93 (dye) Antibody
abx346920-50l	Abbexa	50 µl	EUR 162.5

Nuclear pore complex protein Nup153 Antibody (HRP)
abx108567-100g	Abbexa	100 µg	EUR 362.5

Nuclear pore complex protein Nup153 Antibody (HRP)
20-abx108567	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	20 ug 50 ug 100 ug 200 ug 1 mg

Nuclear pore complex protein Nup153 Antibody (HRP)
abx108567-20g	Abbexa	20 µg	EUR 162.5

Nuclear pore complex protein Nup153 Antibody (HRP)
abx108567-50g	Abbexa	50 µg	EUR 250

Nuclear pore complex protein Nup153 Antibody (FITC)
abx107146-100g	Abbexa	100 µg	EUR 362.5

Nuclear pore complex protein Nup153 Antibody (FITC)
20-abx107146	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	20 ug 50 ug 100 ug 200 ug 1 mg

Nuclear pore complex protein Nup153 Antibody (FITC)
abx107146-20g	Abbexa	20 µg	EUR 162.5

Nuclear pore complex protein Nup153 Antibody (FITC)
abx107146-50g	Abbexa	50 µg	EUR 250

Nuclear pore complex protein NUP62 (NUP62) Antibody
abx349838-96tests	Abbexa	96 tests	EUR 250

Nuclear pore complex protein NUP62 (NUP62) Antibody
abx349839-96tests	Abbexa	96 tests	EUR 250

Nuclear Pore Complex antibody
10R-8370	Fitzgerald	100 ul	EUR 450
Description: Mouse monoclonal Nuclear Pore Complex antibody

Nuclear Pore Complex antibody
MBS838560-01mL	MyBiosource	0.1mL	EUR 735

Nuclear Pore Complex antibody
MBS838560-5x01mL	MyBiosource	5x0.1mL	EUR 3165

Nuclear pore complex protein Nup98 (315-360)
HY-P1730	MedChemExpress	1mg	EUR 1368

Nuclear pore complex protein Nup98 315-360
MBS5763796-1mg	MyBiosource	1mg	EUR 750

Nuclear pore complex protein Nup98 315-360
MBS5763796-5x1mg	MyBiosource	5x1mg	EUR 3230

Nuclear pore complex protein Nup98 315-360
TP1781-10mg	TargetMol Chemicals	10mg	Ask for price
Description: Nuclear pore complex protein Nup98 315-360

Nuclear pore complex protein Nup98 315-360
TP1781-1g	TargetMol Chemicals	1g	Ask for price
Description: Nuclear pore complex protein Nup98 315-360

Nuclear pore complex protein Nup98 315-360
TP1781-1mg	TargetMol Chemicals	1mg	Ask for price
Description: Nuclear pore complex protein Nup98 315-360

Nuclear pore complex protein Nup98 315-360
TP1781-50mg	TargetMol Chemicals	50mg	Ask for price
Description: Nuclear pore complex protein Nup98 315-360

Nuclear pore complex protein Nup98 315-360
TP1781-5mg	TargetMol Chemicals	5mg	Ask for price
Description: Nuclear pore complex protein Nup98 315-360

Nuclear pore complex protein Nup153 Antibody (Biotin)
abx105728-100g	Abbexa	100 µg	EUR 362.5

Nuclear pore complex protein Nup153 Antibody (Biotin)
20-abx105728	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	20 ug 50 ug 100 ug 200 ug 1 mg

Nuclear pore complex protein Nup153 Antibody (Biotin)
abx105728-20g	Abbexa	20 µg	EUR 162.5

Nuclear pore complex protein Nup153 Antibody (Biotin)
abx105728-50g	Abbexa	50 µg	EUR 250

Nuclear pore complex protein Nup153 (NUP153) Antibody
abx402586-100tests	Abbexa	100 tests	EUR 400

Nuclear pore complex protein Nup153 (NUP153) Antibody
abx402586-25tests	Abbexa	25 tests	EUR 287.5

Nuclear pore complex protein Nup93 (dye) Antibody (HRP)
abx346921-100g	Abbexa	100 µg	EUR 362.5

Nuclear pore complex protein Nup93 (dye) Antibody (HRP)
abx346921-20g	Abbexa	20 µg	EUR 162.5

Nuclear pore complex protein Nup93 (dye) Antibody (HRP)
abx346921-50g	Abbexa	50 µg	EUR 250

Nuclear pore complex protein Nup93 (dye) Antibody (FITC)
abx346922-100g	Abbexa	100 µg	EUR 362.5

Nuclear pore complex protein Nup93 (dye) Antibody (FITC)
abx346922-20g	Abbexa	20 µg	EUR 162.5

Nuclear pore complex protein Nup93 (dye) Antibody (FITC)
abx346922-50g	Abbexa	50 µg	EUR 250

Human Nuclear pore complex protein Nup153 (NUP153)
1-CSB-EP016190HU	Cusabio	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	10ug 50ug 100ug 200ug 500ug 1MG
Description: Recombinant Human Nuclear pore complex protein Nup153(NUP153),partial expressed in E.coli

Nuclear pore complex protein Nup93 (dye) Antibody (Biotin)
abx346923-100g	Abbexa	100 µg	EUR 362.5

Nuclear pore complex protein Nup93 (dye) Antibody (Biotin)
abx346923-20g	Abbexa	20 µg	EUR 162.5

Nuclear pore complex protein Nup93 (dye) Antibody (Biotin)
abx346923-50g	Abbexa	50 µg	EUR 250

Nuclear Pore Complex-interacting Protein (NPIP)
MBS621481-005mL	MyBiosource	0.05mL	EUR 660

Nuclear Pore Complex-interacting Protein (NPIP)
MBS621481-5x005mL	MyBiosource	5x0.05mL	EUR 2820

Nuclear pore complex protein Nup98-Nup96 (NUP98) Antibody
abx402602-100g	Abbexa	100 µg	EUR 287.5

Nuclear Pore Complex, Panspecific
MBS6005035-05mL	MyBiosource	0.5(mL	EUR 575

Nuclear Pore Complex, Panspecific
MBS6005035-5x05mL	MyBiosource	5x0.5mL	EUR 2440

Recombinant Human Nuclear pore complex protein Nup153
MBS949865-002mgEColi	MyBiosource	0.02mg(E-Coli)	EUR 255

Recombinant Human Nuclear pore complex protein Nup153
MBS949865-01mgEColi	MyBiosource	0.1mg(E-Coli)	EUR 405

Recombinant Human Nuclear pore complex protein Nup153
MBS949865-1mgEColi	MyBiosource	1mg(E-Coli)	EUR 1425

Recombinant Human Nuclear pore complex protein Nup153
MBS949865-5x1mgEColi	MyBiosource	5x1mg(E-Coli)	EUR 6215

Recombinant Human Nuclear pore complex protein Nup153
MBS9420506-002mg	MyBiosource	0.02mg	EUR 285

Recombinant Human Nuclear pore complex protein Nup153
MBS9420506-01mg	MyBiosource	0.1mg	EUR 470

Recombinant Human Nuclear pore complex protein Nup153
MBS9420506-1mg	MyBiosource	1mg	EUR 1785

Recombinant Human Nuclear pore complex protein Nup153
MBS9420506-5x1mg	MyBiosource	5x1mg	EUR 7885

Recombinant human Nuclear pore complex protein Nup133
P2220	FN Test	100ug	Ask for price
Description: Recombinant protein for human Nuclear pore complex protein Nup133

Nuclear pore complex protein Nup153 monoclonal antibody (QE5)
MBS566758-01mL	MyBiosource	0.1mL	EUR 495

Nuclear pore complex protein Nup153 monoclonal antibody (QE5)
MBS566758-5x01mL	MyBiosource	5x0.1mL	EUR 2185

Rabbit anti-human Nuclear pore complex protein Nup153 polyclonal Antibody
MBS1497638-005mg	MyBiosource	0.05mg	EUR 190

Rabbit anti-human Nuclear pore complex protein Nup153 polyclonal Antibody
MBS1497638-01mg	MyBiosource	0.1mg	EUR 270

Rabbit anti-human Nuclear pore complex protein Nup153 polyclonal Antibody
MBS1497638-5x01mg	MyBiosource	5x0.1mg	EUR 1205

Nuclear Pore Complex Protein Nup98/Nup96 (NUP98/NUP96) Antibody
abx235932-100g	Abbexa	100 µg	EUR 350

Nuclear Pore Complex, nup153 (NPC)
MBS600797-5mL	MyBiosource	5mL	EUR 680

Nuclear Pore Complex, nup153 (NPC)
MBS600797-5x5mL	MyBiosource	5x5mL	EUR 2910

Recombinant Rat Nuclear pore complex protein Nup50 (Nup50)
MBS1159504-002mgBaculovirus	MyBiosource	0.02mg(Baculovirus)	EUR 1335

Recombinant Rat Nuclear pore complex protein Nup50 (Nup50)
MBS1159504-002mgEColi	MyBiosource	0.02mg(E-Coli)	EUR 1025

Recombinant Rat Nuclear pore complex protein Nup50 (Nup50)
MBS1159504-002mgYeast	MyBiosource	0.02mg(Yeast)	EUR 1130

Recombinant Rat Nuclear pore complex protein Nup50 (Nup50)
MBS1159504-01mgEColi	MyBiosource	0.1mg(E-Coli)	EUR 1200

Recombinant Rat Nuclear pore complex protein Nup50 (Nup50)
MBS1159504-01mgYeast	MyBiosource	0.1mg(Yeast)	EUR 1285

Recombinant Rat Nuclear pore complex protein Nup88 (Nup88)
MBS1030551-002mgEColi	MyBiosource	0.02mg(E-Coli)	EUR 1320

Recombinant Rat Nuclear pore complex protein Nup88 (Nup88)
MBS1030551-002mgYeast	MyBiosource	0.02mg(Yeast)	EUR 1350

Recombinant Rat Nuclear pore complex protein Nup88 (Nup88)
MBS1030551-01mgEColi	MyBiosource	0.1mg(E-Coli)	EUR 1595

Recombinant Rat Nuclear pore complex protein Nup88 (Nup88)
MBS1030551-01mgYeast	MyBiosource	0.1mg(Yeast)	EUR 1585

Recombinant Rat Nuclear pore complex protein Nup88 (Nup88)
MBS1030551-002mgBaculovirus	MyBiosource	0.02mg(Baculovirus)	EUR 1590

Recombinant Rat Nuclear pore complex protein Nup85 (Nup85)
MBS1443575-002mgBaculovirus	MyBiosource	0.02mg(Baculovirus)	EUR 1510

Recombinant Rat Nuclear pore complex protein Nup85 (Nup85)
MBS1443575-002mgEColi	MyBiosource	0.02mg(E-Coli)	EUR 1220

Recombinant Rat Nuclear pore complex protein Nup85 (Nup85)
MBS1443575-002mgYeast	MyBiosource	0.02mg(Yeast)	EUR 1270

Recombinant Rat Nuclear pore complex protein Nup85 (Nup85)
MBS1443575-01mgEColi	MyBiosource	0.1mg(E-Coli)	EUR 1470

Recombinant Rat Nuclear pore complex protein Nup85 (Nup85)
MBS1443575-01mgYeast	MyBiosource	0.1mg(Yeast)	EUR 1495

Recombinant Rat Nuclear pore complex protein Nup54 (Nup54)
MBS961320-002mgBaculovirus	MyBiosource	0.02mg(Baculovirus)	EUR 1375

Recombinant Rat Nuclear pore complex protein Nup54 (Nup54)
MBS961320-002mgEColi	MyBiosource	0.02mg(E-Coli)	EUR 1080

Recombinant Rat Nuclear pore complex protein Nup54 (Nup54)
MBS961320-002mgYeast	MyBiosource	0.02mg(Yeast)	EUR 1135

Recombinant Rat Nuclear pore complex protein Nup54 (Nup54)
MBS961320-01mgEColi	MyBiosource	0.1mg(E-Coli)	EUR 1260

Recombinant Rat Nuclear pore complex protein Nup54 (Nup54)
MBS961320-01mgYeast	MyBiosource	0.1mg(Yeast)	EUR 1330

Recombinant Human Nuclear pore complex protein Nup85 (NUP85)
CSB-EP874821HU	Cusabio	10540 mg	Ask for price

Recombinant Human Nuclear pore complex protein Nup85 (NUP85)
CSB-EP874821HU-100ug	Cusabio	100ug	Ask for price
Description: 1-656aa

Recombinant Human Nuclear pore complex protein Nup85 (NUP85)
CSB-EP874821HU-1mg	Cusabio	1mg	Ask for price
Description: 1-656aa

Recombinant Human Nuclear pore complex protein Nup85 (NUP85)
CSB-EP874821HU-20ug	Cusabio	20ug	Ask for price
Description: 1-656aa

Recombinant Human Nuclear pore complex protein Nup85 (NUP85)
CSB-EP874821HUl9	Cusabio	10977 mg	Ask for price

Recombinant Human Nuclear pore complex protein Nup85 (NUP85)
CSB-EP874821HUl9-100ug	Cusabio	100ug	Ask for price
Description: 1-656aa

Recombinant Human Nuclear pore complex protein Nup85 (NUP85)
CSB-EP874821HUl9-1mg	Cusabio	1mg	Ask for price
Description: 1-656aa

Recombinant Human Nuclear pore complex protein Nup85 (NUP85)
CSB-EP874821HUl9-20ug	Cusabio	20ug	Ask for price
Description: 1-656aa

Recombinant Mouse Nuclear pore complex protein Nup85 (Nup85)
MBS1386981-002mgBaculovirus	MyBiosource	0.02mg(Baculovirus)	EUR 1510

Recombinant Mouse Nuclear pore complex protein Nup85 (Nup85)
MBS1386981-002mgEColi	MyBiosource	0.02mg(E-Coli)	EUR 1220

Recombinant Mouse Nuclear pore complex protein Nup85 (Nup85)
MBS1386981-002mgYeast	MyBiosource	0.02mg(Yeast)	EUR 1270

Recombinant Mouse Nuclear pore complex protein Nup85 (Nup85)
MBS1386981-01mgEColi	MyBiosource	0.1mg(E-Coli)	EUR 1470

Recombinant Mouse Nuclear pore complex protein Nup85 (Nup85)
MBS1386981-01mgYeast	MyBiosource	0.1mg(Yeast)	EUR 1495

Recombinant Mouse Nuclear pore complex protein Nup54 (Nup54)
MBS1383866-002mgBaculovirus	MyBiosource	0.02mg(Baculovirus)	EUR 1375

Recombinant Mouse Nuclear pore complex protein Nup54 (Nup54)
MBS1383866-002mgEColi	MyBiosource	0.02mg(E-Coli)	EUR 1080

Recombinant Mouse Nuclear pore complex protein Nup54 (Nup54)
MBS1383866-002mgYeast	MyBiosource	0.02mg(Yeast)	EUR 1135

Recombinant Mouse Nuclear pore complex protein Nup54 (Nup54)
MBS1383866-01mgEColi	MyBiosource	0.1mg(E-Coli)	EUR 1260

Recombinant Mouse Nuclear pore complex protein Nup54 (Nup54)
MBS1383866-01mgYeast	MyBiosource	0.1mg(Yeast)	EUR 1330

Recombinant Mouse Nuclear pore complex protein Nup50 (Nup50)
MBS1323221-002mgBaculovirus	MyBiosource	0.02mg(Baculovirus)	EUR 1335

Recombinant Mouse Nuclear pore complex protein Nup50 (Nup50)
MBS1323221-002mgEColi	MyBiosource	0.02mg(E-Coli)	EUR 1025

Recombinant Mouse Nuclear pore complex protein Nup50 (Nup50)
MBS1323221-002mgYeast	MyBiosource	0.02mg(Yeast)	EUR 1125

Recombinant Mouse Nuclear pore complex protein Nup50 (Nup50)
MBS1323221-01mgEColi	MyBiosource	0.1mg(E-Coli)	EUR 1195

Recombinant Mouse Nuclear pore complex protein Nup50 (Nup50)
MBS1323221-01mgYeast	MyBiosource	0.1mg(Yeast)	EUR 1285

Recombinant Mouse Nuclear pore complex protein Nup88 (Nup88)
MBS1323760-002mgBaculovirus	MyBiosource	0.02mg(Baculovirus)	EUR 1600

Recombinant Mouse Nuclear pore complex protein Nup88 (Nup88)
MBS1323760-002mgEColi	MyBiosource	0.02mg(E-Coli)	EUR 1335

Recombinant Mouse Nuclear pore complex protein Nup88 (Nup88)
MBS1323760-002mgYeast	MyBiosource	0.02mg(Yeast)	EUR 1360

Recombinant Mouse Nuclear pore complex protein Nup88 (Nup88)
MBS1323760-01mgEColi	MyBiosource	0.1mg(E-Coli)	EUR 1610

Recombinant Mouse Nuclear pore complex protein Nup88 (Nup88)
MBS1323760-01mgYeast	MyBiosource	0.1mg(Yeast)	EUR 1600

Recombinant Human Nuclear pore complex protein Nup88 (NUP88)
MBS1448092-002mgBaculovirus	MyBiosource	0.02mg(Baculovirus)	EUR 1590

Recombinant Human Nuclear pore complex protein Nup88 (NUP88)
MBS1448092-002mgEColi	MyBiosource	0.02mg(E-Coli)	EUR 1320

Recombinant Human Nuclear pore complex protein Nup88 (NUP88)
MBS1448092-002mgYeast	MyBiosource	0.02mg(Yeast)	EUR 1350

Recombinant Human Nuclear pore complex protein Nup88 (NUP88)
MBS1448092-01mgEColi	MyBiosource	0.1mg(E-Coli)	EUR 1595

Recombinant Human Nuclear pore complex protein Nup88 (NUP88)
MBS1448092-01mgYeast	MyBiosource	0.1mg(Yeast)	EUR 1585

Recombinant Human Nuclear pore complex protein Nup50 (NUP50)
MBS1433733-002mgBaculovirus	MyBiosource	0.02mg(Baculovirus)	EUR 1335

Recombinant Human Nuclear pore complex protein Nup50 (NUP50)
MBS1433733-002mgEColi	MyBiosource	0.02mg(E-Coli)	EUR 1030

Recombinant Human Nuclear pore complex protein Nup50 (NUP50)
MBS1433733-002mgYeast	MyBiosource	0.02mg(Yeast)	EUR 1130

Recombinant Human Nuclear pore complex protein Nup50 (NUP50)
MBS1433733-01mgEColi	MyBiosource	0.1mg(E-Coli)	EUR 1200

Recombinant Human Nuclear pore complex protein Nup50 (NUP50)
MBS1433733-01mgYeast	MyBiosource	0.1mg(Yeast)	EUR 1285

Recombinant Human Nuclear pore complex protein Nup85 (NUP85)
MBS1473301-002mgBaculovirus	MyBiosource	0.02mg(Baculovirus)	EUR 1510

Recombinant Human Nuclear pore complex protein Nup85 (NUP85)
MBS1473301-002mgEColi	MyBiosource	0.02mg(E-Coli)	EUR 1220

Recombinant Human Nuclear pore complex protein Nup85 (NUP85)
MBS1473301-002mgYeast	MyBiosource	0.02mg(Yeast)	EUR 1270

These observations indicate that the MAPS and a threshold level of MT acetylation / deacetylation is important for MT dynamicity in sperm and may play a role in regulating sperm motility.