Comparison of the ELISA and ECL Assay for Vedolizumab Anti-drug Antibodies: Assessing the Impact on Pharmacokinetics and Safety Outcomes of the Phase 3 GEMINI Trials

Vedolizumab immunogenicity was assessed using an enzyme-linked immunosorbent assay (ELISA) with ~ 0.5 ug / mL drug disorders, which may underestimate the on-drug immunogenicity. We aimed to compare the results between ELISA and immunogenicity of a new drug-tolerant electrochemiluminescence (ECL) assay (and two versions of neutralizing tests, drug-sensitive to the drug-tolerant).

ECL assay drug tolerance is ~ 100 times higher than the ELISA (≥ 50 mg / mL vs 0.5 ug / mL to 500 ng / mL positive control), and the sensitivity of the test is <5 ng / mL for both tests. Vedolizumab immunogenicity rated at 2000 GEMINI 1 and 2 patients initially tested by ELISA and retested by the ECL assay. anti-drug antibodies (ADA) results in infusion-related reactions-and pharmacokinetic (PK) was examined using descriptive statistics and population PK analysis.

With the ECL assay, 6% (86/1427) of patients treated with vedolizumab as induction and maintenance therapy ADA-positive tested. Of these, 20 patients with persistent positive and 56 had a neutralizing antibody. By ELISA, 4% (56/1434) of this ADA-positive patients, 9 were constantly positive, and 33 have antibodies. Among 61 patients with infusion-related reactions, 6 (10%) is ADA-positive (2 continuous positive) by ECL assay. By ELISA, 3 (5%) both ADA-positive patients and constantly positive.

Partial results (96%) was similar in both tests. In a population PK models are updated, ADA-positive status is expected to increase linearly vedolizumab clearance by a factor of 1.10 (95% credible interval 1.03 to 1.17), consistent with previous reports. ADA impacts the safety and PK modeling generally remained consistently good using ELISA or ECL assay.

Antitumor effect of humanized anti-tissue factor antibody-drug conjugate in a model of peritoneal disseminated pancreatic cancer

tissue factor (TF) is an attractive target for cancer therapy due to excess in some kinds of malignancies. Additionally, TF has been reported to play a functional role both in the development of cancer and metastasis. Several groups have developed antibody-drug conjugate (ADC) to the TF to be used as a cancer treatment, and has demonstrated efficacy in subcutaneous xenograft models of conventional and patient-derived xenograft model.

However, no previous studies have investigated the effectiveness of anti-TF ADC model with advanced cancer. This study developed the original anti-human TF monoclonal antibody conjugated to monomethyl auristatin E, and evaluated its efficacy in vivo in a xenograft model of pancreatic cancer with peritoneal dissemination. An in vitro study showed that the anti-TF ADC has a strong binding affinity and cytotoxic activity against human pancreatic cancer cells highly expressed TF antigen.

Anti-TF ADC also show greater antitumor effect than the ADC control in the conventional subcutaneous xenograft models, with efficacy depends on TF expression in the tumor tissue. Furthermore, the anti-TF ADC significantly inhibited tumor growth in an orthotopic xenograft model, and extend the lifespan in a murine model of peritoneal dissemination. These results suggest that anti-TF ADC has the potential to be an effective treatment not only for the primary tumor, but also for those who disseminated widely. Therefore, it can be concluded that the ADC targeting TF may be a promising agent for the treatment of advanced pancreatic cancer.

 

Treatment of Antibody-Mediated Rejection After Kidney Transplant: Effects immunology, clinical response, and histologic findings

BACKGROUND antibody-mediated rejection (AMR) prize with clinical manifestations are diverse and may have a potential negative impact on graft function and survival. If not treated successfully, AMR can lead to a 20-30% loss of the graft after one year. Little is known about the efficacy of the treatment of the AMR, and the most appropriate treatment strategy has not been determined.

This study evaluated the effects of AMR treatment with plasmapheresis (PP) and intravenous immunoglobulin (IVIG) on renal function, the intensity of anti-HLA antibodies, and graft biopsy morphology. MATERIALS AND METHODS retrospective cohort study of this center including AMR kidney transplant recipients with biopsy treated with PP and / or IVIG. clinical findings, mean fluorescence intensity of donor-specific antibodies anti-HLA (DSA), and graft histology findings, classified according to the Park scored at the time of AMR and 6 and 12 months later, were evaluated.

Results Of the 42 patients who met the inclusion criteria, 38 (90.5%) received IVIG and 26 (61.9%) underwent PP. At AMR diagnosis, 36 (85.7%) patients had proteinuria, with an estimated glomerular filtration rate they remained stable during follow-up. During the first year, 8 (19.0%) patients experienced graft failure, but did not die with a functioning graft. The decline of class I panel reactive antibodies were observed 6 and 12 months after treatment AMR, with a significant reduction in the DSA-A and -B fluorescence intensity, but there is no change in the DSA-DQ. Graft biopsy showed a reduction in inflammation and score C4D, without any improvement in microvascular inflammation. CONCLUSION AMR reduce treatment related biopsy and serological markers AMR, but does not affect the DSA-DQ.

Tryptophan Oxidation of Monoclonal Antibody under Various Conditions Oxidative Stress: Preparation oxidative Specific Favor Unlike tryptophan residue

oxidation of tryptophan could play an important role in choosing a therapeutic monoclonal antibody for commercialization. Monoclonal antibodies that harbor very sensitive tryptophan residue is usually discarded in favor of antibodies oxidation resistance.

Tryptophan residue individual susceptibility to oxidation is usually evaluated through the forced degradation studies during the development process of molecules. We compared the results of some general forced degradation „stress test” for any tryptophan residues in the monoclonal antibody and found that the oxidation state of high stress consistently give different ratings across the tryptophan residue oxidative sensitivity of individuals compared with long-term thermal stability or low stress conditions. We then determined that this difference in ranking is largely due to an overabundance of double oxidation (ie detected as 32 Da) specific tryptophan residue under high stress conditions as compared to a single oxidation (ie 16 Da).

Axl (untagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 1, (10ug)

MC222408 10 µg Ask for price

Mouse AXL Antibody Pair Set

ABPR-ZB130 5 plates, 15 plates Ask for price
Description: Quantitative determination of Mouse AXL

Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 2

MR222556 10 µg Ask for price

Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 3

MR222558 10 µg Ask for price

Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 1

MR211073 10 µg Ask for price

Axl (GFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl) transcript variant 2, (10ug)

MG222556 10 µg Ask for price

Axl (GFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl) transcript variant 3, (10ug)

MG222558 10 µg Ask for price

anti- AXL antibody

FNab00754 100µg
EUR 606.3
Description: Antibody raised against AXL

Mouse AXL ELISA Kit

EK5264 96 tests
EUR 599

Mouse AXL ELISA Kit

E28L0663 96T
EUR 666.67

Mouse AXL ELISA Kit

LF-EK50868 1×96T
EUR 777.6

Rat Monoclonal anti-mouse Axl

mAP-0022 100ug
EUR 250

Mouse AXL shRNA Plasmid

20-abx973661
  • Ask for price
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  • 150 µg
  • 300 µg

Mouse Monoclonal Antibody to AXL

MAB-606020332 0.1ml
EUR 280

Mouse Monoclonal Antibody to AXL

sAP-0203 50ug
EUR 270

Mouse Monoclonal Antibody to AXL

sAP-0273 50ug
EUR 270

Mouse Monoclonal Antiobody to AXL

MAB-606020250 0.1ml
EUR 260

Mouse Monoclonal Anti-Human AXL protein IgG-Biotinylated

AXL13-BTN 100 ul
EUR 634.8

Mouse Monoclonal Anti-Human AXL protein IgG, aff pure

AXL13-M 100 ul
EUR 578.4

Lenti ORF clone of Axl (mGFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 2

MR222556L4 10 µg Ask for price

Lenti ORF clone of Axl (mGFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 3

MR222558L4 10 µg Ask for price

Lenti ORF clone of Axl (mGFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 1

MR211073L2 10 µg Ask for price

Lenti ORF clone of Axl (mGFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 1

MR211073L4 10 µg Ask for price

Mouse AXL Protein, His Tag

E40MOP1139 20ug
EUR 495

Mouse AXL PicoKine ELISA Kit

EK0660 96 wells
EUR 510
Description: For quantitative detection of mouse AXL in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Anti-Human Axl Antibody

101-M222 100 µg
EUR 399
Description: Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt), and Mer (human and mouse homologues of chicken cEyk) constitute a subfamily of the receptor tyrosine kinases. The extracellular domains of these proteins contain two Iglike motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. The human Axl cDNA encodes an 887 amino acid (aa) precursor that includes an 18 aa signal sequence, a 426 aa extracellular domain, a 21 aa transmembrane segment, and a 422 aa cytoplasmic domain. The extracellular domains of human and mouse Axl share 81% aa sequence identity. A short alternately spliced form of human Axl is distinguished by a 9 aa deletion in the extracellular juxtamembrane region. These receptors bind the vitamin K dependent protein growth arrest specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration, or the prevention of apoptosis. This family of tyrosine kinase receptors is involved in hematopoiesis, embryonic development, tumorigenesis, and regulation of testicular functions.

Axl ORF Vector (Mouse) (pORF)

ORF039463 1.0 ug DNA
EUR 607.2

Axl ORF Vector (Mouse) (pORF)

ORF039464 1.0 ug DNA
EUR 607.2

Axl ORF Vector (Mouse) (pORF)

ORF039465 1.0 ug DNA
EUR 607.2

Lenti ORF clone of Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 2

MR222556L3 10 µg Ask for price

Lenti ORF clone of Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 3

MR222558L3 10 µg Ask for price

Lenti ORF clone of Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 1

MR211073L1 10 µg Ask for price

Lenti ORF clone of Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 1

MR211073L3 10 µg Ask for price

AXL ELISA Kit (Mouse) (OKBB00412)

OKBB00412 96 Wells
EUR 606
Description: Description of target: Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene. The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. Axl is a chronic myelogenous leukemia-associated oncogene and also associated with colon cancer and melanoma. It is in close vicinity to the bcl3 oncogene, which is at 19q13.1-q13.2. The Axl gene is evolutionarily conserved between vertebrate species. This gene has two different alternatively spliced transcript variants.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL

Nori® Mouse Axl ELISA Kit

GR117424 96-well
EUR 461

Mouse AXL Protein, Fc & His Tag

E40MOP1138 20ug
EUR 495

Lenti ORF particles, Axl (GFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 2, 200ul, >10^7 TU/mL

MR222556L4V 200 µl Ask for price

Lenti ORF particles, Axl (GFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 3, 200ul, >10^7 TU/mL

MR222558L4V 200 µl Ask for price

Lenti ORF particles, Axl (GFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 1, 200ul, >10^7 TU/mL

MR211073L2V 200 µl Ask for price

Lenti ORF particles, Axl (GFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 1, 200ul, >10^7 TU/mL

MR211073L4V 200 µl Ask for price

AXL mouse monoclonal antibody, clone 7E10, Ascites

AM06326SU-N 100 µl Ask for price

AXL mouse monoclonal antibody, clone 1B3A2, Ascites

AM06260SU-N 100 µl Ask for price

OKRC01096-96W - Axl ELISA Kit (Mouse)

OKRC01096-96W 96Wells
EUR 525

OKBB00412-96W - AXL ELISA Kit (Mouse)

OKBB00412-96W 96Wells
EUR 538

Rabbit Anti-Mouse AXL protein IgG-Biotinylated

AXL11-BTN 100 ul
EUR 634.8

Lenti ORF particles, Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 2, 200ul, >10^7 TU/mL

MR222556L3V 200 µl Ask for price

Lenti ORF particles, Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 3, 200ul, >10^7 TU/mL

MR222558L3V 200 µl Ask for price

Lenti ORF particles, Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 1, 200ul, >10^7 TU/mL

MR211073L1V 200 µl Ask for price

Lenti ORF particles, Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 1, 200ul, >10^7 TU/mL

MR211073L3V 200 µl Ask for price

Sheep Polyclonal anti-human AXL

hAP-5038 50ug
EUR 400

Axl sgRNA CRISPR Lentivector set (Mouse)

K4394001 3 x 1.0 ug
EUR 406.8

AXL antibody

10R-1995 100 ul
EUR 374
Description: Mouse monoclonal AXL antibody

AXL antibody

10R-2051 100 ul
EUR 468
Description: Mouse monoclonal AXL antibody

Axl Antibody

39365-100ul 100ul
EUR 468

AXL Antibody

48205 100ul
EUR 429

AXL Antibody

48205-100ul 100ul
EUR 399.6

AXL Antibody

48205-50ul 50ul
EUR 286.8

AXL Antibody

1-CSB-PA030245
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  • 100ug
  • 50ug
Description: A polyclonal antibody against AXL. Recognizes AXL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000

AXL Antibody

E10-20250 100μg/100μl
EUR 225
Description: Available in various conjugation types.

AXL Antibody

E10-20332 100μg/100μl
EUR 225
Description: Available in various conjugation types.

AXL Antibody

F44438-0.08ML 0.08 ml
EUR 140.25
Description: AXL may function as a signal transducer between specific cell types of mesodermal origin.

AXL Antibody

F44438-0.4ML 0.4 ml
EUR 322.15
Description: AXL may function as a signal transducer between specific cell types of mesodermal origin.

AXL Antibody

F50552-0.08ML 0.08 ml
EUR 140.25
Description: AXL, a member of the AXL/UFO subfamily of Tyr protein kinases, may function as a signal transducer between specific cell types of mesodermal origin. This Type I membrane protein has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia. The protein contains 2 putative fibronectin type III domains and 2 putative immunoglobulin-like C2-type domains.

AXL Antibody

F50552-0.4ML 0.4 ml
EUR 322.15
Description: AXL, a member of the AXL/UFO subfamily of Tyr protein kinases, may function as a signal transducer between specific cell types of mesodermal origin. This Type I membrane protein has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia. The protein contains 2 putative fibronectin type III domains and 2 putative immunoglobulin-like C2-type domains.

AXL Antibody

F50553-0.08ML 0.08 ml
EUR 140.25
Description: AXL, a member of the AXL/UFO subfamily of Tyr protein kinases, may function as a signal transducer between specific cell types of mesodermal origin. This Type I membrane protein has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia. The protein contains 2 putative fibronectin type III domains and 2 putative immunoglobulin-like C2-type domains.

AXL Antibody

F50553-0.4ML 0.4 ml
EUR 322.15
Description: AXL, a member of the AXL/UFO subfamily of Tyr protein kinases, may function as a signal transducer between specific cell types of mesodermal origin. This Type I membrane protein has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia. The protein contains 2 putative fibronectin type III domains and 2 putative immunoglobulin-like C2-type domains.

AXL Antibody

F50554-0.08ML 0.08 ml
EUR 140.25
Description: GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. [UniProt]

AXL Antibody

F50554-0.4ML 0.4 ml
EUR 322.15
Description: GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. [UniProt]

AXL Antibody

E306043 200ul
EUR 275
Description: Available in various conjugation types.

Axl Antibody

E90532 100ul
EUR 255
Description: Available in various conjugation types.

AXL Antibody

F53357-0.08ML 0.08 ml
EUR 140.25
Description: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor. [UniProt]

AXL Antibody

F53357-0.4ML 0.4 ml
EUR 322.15
Description: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor. [UniProt]

Axl Antibody

E300616 100ug
EUR 275
Description: Available in various conjugation types.

AXL Antibody

E38PA5315 100ul
EUR 225
Description: Available in various conjugation types.

AXL Antibody

AF6824 100ul
EUR 420

AXL Antibody

AF6824-100ul 100ul
EUR 280

AXL Antibody

AF6824-200ul 200ul
EUR 350

AXL antibody

70R-9655 50 ug
EUR 467
Description: Affinity purified rabbit polyclonal AXL antibody

AXL antibody

70R-51253 100 ul
EUR 286
Description: Purified Polyclonal AXL antibody

AXL Antibody

BF0290 200ul
EUR 540

AXL Antibody

BF0290-100ul 100ul
EUR 350

AXL Antibody

BF0290-200ul 200ul
EUR 450

AXL Antibody

BF0290-50ul 50ul
EUR 250

AXL Antibody

AF7793 200ul
EUR 540

AXL Antibody

AF7793-100ul 100ul
EUR 350

AXL Antibody

AF7793-200ul 200ul
EUR 450

AXL Antibody

AF7793-50ul 50ul
EUR 250

AXL Antibody

AF8412 200ul
EUR 540

AXL Antibody

AF8412-100ul 100ul
EUR 350

AXL Antibody

AF8412-200ul 200ul
EUR 450

AXL Antibody

AF8412-50ul 50ul
EUR 250

AXL Antibody

CAC11246-100ug 100ug
EUR 314

AXL Antibody

CAC11246-50ug 50ug
EUR 199.2

AXL Antibody

1-CSB-PA297707
  • Ask for price
  • Ask for price
  • 100ug
  • 50ug
Description: A polyclonal antibody against AXL. Recognizes AXL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000

AXL Antibody

1-CSB-PA326981LA01HU
  • Ask for price
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  • 100ug
  • 50ug
Description: A polyclonal antibody against AXL. Recognizes AXL from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200

AXL Antibody

ABF8412 100 ug
EUR 525.6

AXL Antibody

RQ6041 100 ug
EUR 356.15
Description: Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene. This gene is mapped to 19q13.2. The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene.

AXL Antibody

GWB-MV464E 50ug Ask for price

AXL

E8R1406-3 100ul
EUR 275
Description: Available in various conjugation types.

AXL

CSB-CL326981HU 10 μg plasmid + 200μl Glycerol Ask for price

Rabbit Anti-Mouse AXL protein IgG, aff pure

AXL11-A 100 ul
EUR 578.4

Axl Protein Vector (Mouse) (pPM-C-HA)

PV157852 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPM-C-HA)

PV157856 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPM-C-HA)

PV157860 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPB-C-His)

PV157850 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPB-N-His)

PV157851 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPM-C-His)

PV157853 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPB-C-His)

PV157854 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPB-N-His)

PV157855 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPM-C-His)

PV157857 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPB-C-His)

PV157858 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPB-N-His)

PV157859 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPM-C-His)

PV157861 500 ng
EUR 1278

Mouse AXL Receptor Tyrosine Kinase ELISA kit

E01A19041 96T
EUR 700
Description: ELISA

Recombinant Mouse Axl Kinase Protein (His Tag)

PKSM040849-100ug 100ug
EUR 732
Description: Mouse

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody

CAU21502-100ul 100ul
EUR 281.3

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody

CAU21502-200ul 200ul
EUR 351.1

Rabbit Anti-Mouse AXL monoclonal antibody, clone S210

CABT-ZB554 50 μl
EUR 520
Description: Rabbit

Rabbit Anti-Mouse AXL monoclonal antibody, clone S126

CABT-ZB916 50 μl
EUR 520
Description: Rabbit

Axl sgRNA CRISPR Lentivector (Mouse) (Target 1)

K4394002 1.0 ug DNA
EUR 184.8

Axl sgRNA CRISPR Lentivector (Mouse) (Target 2)

K4394003 1.0 ug DNA
EUR 184.8

Axl sgRNA CRISPR Lentivector (Mouse) (Target 3)

K4394004 1.0 ug DNA
EUR 184.8

anti-AXL

YF-PA27171 100 ul
EUR 483.6
Description: Rabbit polyclonal to AXL

anti-AXL

YF-PA10419 50 ul
EUR 435.6
Description: Mouse polyclonal to AXL

anti-AXL

YF-PA10420 50 ug
EUR 435.6
Description: Mouse polyclonal to AXL

anti-AXL

YF-PA10421 100 ug
EUR 483.6
Description: Rabbit polyclonal to AXL

anti-AXL

YF-PA23279 50 ul
EUR 400.8
Description: Mouse polyclonal to AXL

Polyclonal Antibody to AXL Receptor Tyrosine Kinase (AXL)

PAL230Ra01 100ul
EUR 293

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat)

4-PAL230Ra01
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  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL)

Recombinant Mouse Axl Kinase Protein (His & Fc Tag)

PKSM040850-100ug 100ug
EUR 732
Description: Mouse

Recombinant AXL Receptor Tyrosine Kinase (AXL)

RPU54005-100ug 100ug
EUR 566.5

Recombinant AXL Receptor Tyrosine Kinase (AXL)

RPU54005-1mg 1mg
EUR 2511.6

Recombinant AXL Receptor Tyrosine Kinase (AXL)

RPU54005-50ug 50ug
EUR 455.4

Recombinant AXL Receptor Tyrosine Kinase (AXL)

RPU56028-100ug 100ug
EUR 514.8

Recombinant AXL Receptor Tyrosine Kinase (AXL)

RPU56028-1mg 1mg
EUR 2607.8

Recombinant AXL Receptor Tyrosine Kinase (AXL)

RPU56028-50ug 50ug
EUR 401.3

Recombinant AXL Receptor Tyrosine Kinase (AXL)

RPL230Hu01 10ug
EUR 167

Recombinant AXL Receptor Tyrosine Kinase (AXL)

4-RPL230Hu01
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  • Ask for price
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  • Ask for price
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human AXL Receptor Tyrosine Kinase expressed in: E.coli

Recombinant AXL Receptor Tyrosine Kinase (AXL)

RPL230Ra01 10ug
EUR 184

Recombinant AXL Receptor Tyrosine Kinase (AXL)

4-RPL230Ra01
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat AXL Receptor Tyrosine Kinase expressed in: E.coli

AXL (untagged)-Human AXL receptor tyrosine kinase (AXL), transcript variant 1

SC112559 10 µg Ask for price

AXL (untagged)-Human AXL receptor tyrosine kinase (AXL), transcript variant 2

SC125242 10 µg Ask for price

AXL (untagged) - Human AXL receptor tyrosine kinase (AXL), transcript variant 3

SC337032 10 µg Ask for price

AXL (pY691) Antibody

20-abx249424
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  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

AXL (pY691) Antibody

abx148474-100ug 100 ug
EUR 526.8

AXL (pY702) Antibody

abx148475-100ug 100 ug
EUR 526.8

AXL (pT697) Antibody

20-abx009871
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  • 100 ul
  • 200 ul
  • 30 ul

AXL (pY691) Antibody

abx249424-96tests 96 tests
EUR 43.75

AXL antibody (Tyr691)

70R-32634 100 ug
EUR 294
Description: Rabbit polyclonal AXL antibody (Tyr691)

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), PE

4-PAL230Ra01-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with PE.

AXL siRNA

20-abx908739
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  • 15 nmol
  • 30 nmol

AXL siRNA

20-abx908740
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  • 15 nmol
  • 30 nmol

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), APC

4-PAL230Ra01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with APC.

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), Cy3

4-PAL230Ra01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with Cy3.

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), HRP

4-PAL230Ra01-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with HRP.

AXL Polyclonal Antibody

E917874 100ul
EUR 225
Description: Available in various conjugation types.

Axl Polyclonal Antibody

E20-70426 100ug
EUR 225
Description: Available in various conjugation types.

Axl Polyclonal Antibody

E20-75690 100ug
EUR 225
Description: Available in various conjugation types.

Polyclonal AXL Antibody

APR05948G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AXL . This antibody is tested and proven to work in the following applications:

AXL Conjugated Antibody

C48205 100ul
EUR 476.4

Axl Polyclonal Antibody

ABP57379-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y691

Axl Polyclonal Antibody

ABP57379-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y691

Axl Polyclonal Antibody

ABP57379-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y691

Axl Polyclonal Antibody

ABP55772-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y697

Axl Polyclonal Antibody

ABP55772-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y697

Axl Polyclonal Antibody

ABP55772-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y697

We assume that this is actually a double oxidation mechanically different from the single oxidation is observed and that the high stress conditions support the oxidation mechanism of double (and double oxidation sensitive tryptophan residue) whereas the single oxidation appears to be the main mode of H2O2 oxidation under pressure and length of a term thermal stability and favors a different tryptophan residues are more prone to oxidation mechanism single.

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