19 listopada, 2020
Antibodies, Assay Kits, Biology Cells, cDNA, Culture Cells, Devices, DNA, Dna Testing, Elisa Kits, Equipments, Gels, Isotypes, NATtrol, Panel, Particles, PCR, Pcr Kits, Peptides, Reagents, Recombinant Proteins, Ria Kits, Test Kits, Uncategorized, Vector & Virus, Western Blot
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Comparison of the ELISA and ECL Assay for Vedolizumab Anti-drug Antibodies: Assessing the Impact on Pharmacokinetics and Safety Outcomes of the Phase 3 GEMINI Trials

Vedolizumab immunogenicity was assessed using an enzyme-linked immunosorbent assay (ELISA) with ~ 0.5 ug / mL drug disorders, which may underestimate the on-drug immunogenicity. We aimed to compare the results between ELISA and immunogenicity of a new drug-tolerant electrochemiluminescence (ECL) assay (and two versions of neutralizing tests, drug-sensitive to the drug-tolerant).

ECL assay drug tolerance is ~ 100 times higher than the ELISA (≥ 50 mg / mL vs 0.5 ug / mL to 500 ng / mL positive control), and the sensitivity of the test is <5 ng / mL for both tests. Vedolizumab immunogenicity rated at 2000 GEMINI 1 and 2 patients initially tested by ELISA and retested by the ECL assay. anti-drug antibodies (ADA) results in infusion-related reactions-and pharmacokinetic (PK) was examined using descriptive statistics and population PK analysis.

With the ECL assay, 6% (86/1427) of patients treated with vedolizumab as induction and maintenance therapy ADA-positive tested. Of these, 20 patients with persistent positive and 56 had a neutralizing antibody. By ELISA, 4% (56/1434) of this ADA-positive patients, 9 were constantly positive, and 33 have antibodies. Among 61 patients with infusion-related reactions, 6 (10%) is ADA-positive (2 continuous positive) by ECL assay. By ELISA, 3 (5%) both ADA-positive patients and constantly positive.

Partial results (96%) was similar in both tests. In a population PK models are updated, ADA-positive status is expected to increase linearly vedolizumab clearance by a factor of 1.10 (95% credible interval 1.03 to 1.17), consistent with previous reports. ADA impacts the safety and PK modeling generally remained consistently good using ELISA or ECL assay.

Antitumor effect of humanized anti-tissue factor antibody-drug conjugate in a model of peritoneal disseminated pancreatic cancer

tissue factor (TF) is an attractive target for cancer therapy due to excess in some kinds of malignancies. Additionally, TF has been reported to play a functional role both in the development of cancer and metastasis. Several groups have developed antibody-drug conjugate (ADC) to the TF to be used as a cancer treatment, and has demonstrated efficacy in subcutaneous xenograft models of conventional and patient-derived xenograft model.

However, no previous studies have investigated the effectiveness of anti-TF ADC model with advanced cancer. This study developed the original anti-human TF monoclonal antibody conjugated to monomethyl auristatin E, and evaluated its efficacy in vivo in a xenograft model of pancreatic cancer with peritoneal dissemination. An in vitro study showed that the anti-TF ADC has a strong binding affinity and cytotoxic activity against human pancreatic cancer cells highly expressed TF antigen.

Anti-TF ADC also show greater antitumor effect than the ADC control in the conventional subcutaneous xenograft models, with efficacy depends on TF expression in the tumor tissue. Furthermore, the anti-TF ADC significantly inhibited tumor growth in an orthotopic xenograft model, and extend the lifespan in a murine model of peritoneal dissemination. These results suggest that anti-TF ADC has the potential to be an effective treatment not only for the primary tumor, but also for those who disseminated widely. Therefore, it can be concluded that the ADC targeting TF may be a promising agent for the treatment of advanced pancreatic cancer.

 

Treatment of Antibody-Mediated Rejection After Kidney Transplant: Effects immunology, clinical response, and histologic findings

BACKGROUND antibody-mediated rejection (AMR) prize with clinical manifestations are diverse and may have a potential negative impact on graft function and survival. If not treated successfully, AMR can lead to a 20-30% loss of the graft after one year. Little is known about the efficacy of the treatment of the AMR, and the most appropriate treatment strategy has not been determined.

This study evaluated the effects of AMR treatment with plasmapheresis (PP) and intravenous immunoglobulin (IVIG) on renal function, the intensity of anti-HLA antibodies, and graft biopsy morphology. MATERIALS AND METHODS retrospective cohort study of this center including AMR kidney transplant recipients with biopsy treated with PP and / or IVIG. clinical findings, mean fluorescence intensity of donor-specific antibodies anti-HLA (DSA), and graft histology findings, classified according to the Park scored at the time of AMR and 6 and 12 months later, were evaluated.

Results Of the 42 patients who met the inclusion criteria, 38 (90.5%) received IVIG and 26 (61.9%) underwent PP. At AMR diagnosis, 36 (85.7%) patients had proteinuria, with an estimated glomerular filtration rate they remained stable during follow-up. During the first year, 8 (19.0%) patients experienced graft failure, but did not die with a functioning graft. The decline of class I panel reactive antibodies were observed 6 and 12 months after treatment AMR, with a significant reduction in the DSA-A and -B fluorescence intensity, but there is no change in the DSA-DQ. Graft biopsy showed a reduction in inflammation and score C4D, without any improvement in microvascular inflammation. CONCLUSION AMR reduce treatment related biopsy and serological markers AMR, but does not affect the DSA-DQ.

Tryptophan Oxidation of Monoclonal Antibody under Various Conditions Oxidative Stress: Preparation oxidative Specific Favor Unlike tryptophan residue

oxidation of tryptophan could play an important role in choosing a therapeutic monoclonal antibody for commercialization. Monoclonal antibodies that harbor very sensitive tryptophan residue is usually discarded in favor of antibodies oxidation resistance.

Tryptophan residue individual susceptibility to oxidation is usually evaluated through the forced degradation studies during the development process of molecules. We compared the results of some general forced degradation „stress test” for any tryptophan residues in the monoclonal antibody and found that the oxidation state of high stress consistently give different ratings across the tryptophan residue oxidative sensitivity of individuals compared with long-term thermal stability or low stress conditions. We then determined that this difference in ranking is largely due to an overabundance of double oxidation (ie detected as 32 Da) specific tryptophan residue under high stress conditions as compared to a single oxidation (ie 16 Da).

Mouse AXL PicoKine ELISA Kit
EK0660 96 wells
EUR 510
Description: For quantitative detection of mouse AXL in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Mouse Monoclonal Anti-Human AXL protein IgG-Biotinylated
AXL13-BTN 100 ul
EUR 634.8

Axl ORF Vector (Mouse) (pORF)
ORF039463 1.0 ug DNA
EUR 607.2

Axl ORF Vector (Mouse) (pORF)
ORF039464 1.0 ug DNA
EUR 607.2

Axl ORF Vector (Mouse) (pORF)
ORF039465 1.0 ug DNA
EUR 607.2

Mouse Monoclonal Anti-Human AXL protein IgG, aff pure
AXL13-M 100 ul
EUR 578.4

AXL ELISA Kit (Mouse) (OKBB00412)
OKBB00412 96 Wells
EUR 606
Description: Description of target: Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene. The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. Axl is a chronic myelogenous leukemia-associated oncogene and also associated with colon cancer and melanoma. It is in close vicinity to the bcl3 oncogene, which is at 19q13.1-q13.2. The Axl gene is evolutionarily conserved between vertebrate species. This gene has two different alternatively spliced transcript variants.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL

Nori® Mouse Axl ELISA Kit
GR117424 96-well
EUR 461

Mouse AXL Protein, Fc & His Tag
E40MOP1138 20ug
EUR 495

Axl sgRNA CRISPR Lentivector set (Mouse)
K4394001 3 x 1.0 ug
EUR 406.8

AXL
E8R1406-3 100ul
EUR 275
Description: Available in various conjugation types.

AXL antibody
10R-1995 100 ul
EUR 392.4
Description: Mouse monoclonal AXL antibody

AXL antibody
10R-2051 100 ul
EUR 483.6
Description: Mouse monoclonal AXL antibody

Axl Antibody
39365-100ul 100ul
EUR 468

AXL antibody
70R-9655 50 ug
EUR 560.4
Description: Affinity purified rabbit polyclonal AXL antibody

AXL antibody
70R-51253 100 ul
EUR 344.4
Description: Purified Polyclonal AXL antibody

AXL Antibody
48205-100ul 100ul
EUR 399.6

AXL Antibody
48205-50ul 50ul
EUR 286.8

AXL Antibody
ABF8412 100 ug
EUR 525.6

AXL Antibody
1-CSB-PA030245
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AXL. Recognizes AXL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000

AXL Antibody
1-CSB-PA297707
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AXL. Recognizes AXL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000

AXL Antibody
1-CSB-PA326981LA01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AXL. Recognizes AXL from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200

AXL Antibody
F50552-0.08ML 0.08 ml
EUR 140.25
Description: AXL, a member of the AXL/UFO subfamily of Tyr protein kinases, may function as a signal transducer between specific cell types of mesodermal origin. This Type I membrane protein has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia. The protein contains 2 putative fibronectin type III domains and 2 putative immunoglobulin-like C2-type domains.

AXL Antibody
F50552-0.4ML 0.4 ml
EUR 322.15
Description: AXL, a member of the AXL/UFO subfamily of Tyr protein kinases, may function as a signal transducer between specific cell types of mesodermal origin. This Type I membrane protein has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia. The protein contains 2 putative fibronectin type III domains and 2 putative immunoglobulin-like C2-type domains.

AXL Antibody
F50553-0.08ML 0.08 ml
EUR 140.25
Description: AXL, a member of the AXL/UFO subfamily of Tyr protein kinases, may function as a signal transducer between specific cell types of mesodermal origin. This Type I membrane protein has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia. The protein contains 2 putative fibronectin type III domains and 2 putative immunoglobulin-like C2-type domains.

AXL Antibody
F50553-0.4ML 0.4 ml
EUR 322.15
Description: AXL, a member of the AXL/UFO subfamily of Tyr protein kinases, may function as a signal transducer between specific cell types of mesodermal origin. This Type I membrane protein has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia. The protein contains 2 putative fibronectin type III domains and 2 putative immunoglobulin-like C2-type domains.

AXL Antibody
F50554-0.08ML 0.08 ml
EUR 140.25
Description: GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. [UniProt]

AXL Antibody
F50554-0.4ML 0.4 ml
EUR 322.15
Description: GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. [UniProt]

AXL Antibody
F53357-0.08ML 0.08 ml
EUR 140.25
Description: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor. [UniProt]

AXL Antibody
F53357-0.4ML 0.4 ml
EUR 322.15
Description: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor. [UniProt]

AXL Antibody
F44438-0.08ML 0.08 ml
EUR 140.25
Description: AXL may function as a signal transducer between specific cell types of mesodermal origin.

AXL Antibody
F44438-0.4ML 0.4 ml
EUR 322.15
Description: AXL may function as a signal transducer between specific cell types of mesodermal origin.

AXL Antibody
RQ6041 100 ug
EUR 356.15
Description: Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene. This gene is mapped to 19q13.2. The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene.

AXL Antibody
E38PA5315 100ul
EUR 225
Description: Available in various conjugation types.

Axl Antibody
E90532 100ul
EUR 255
Description: Available in various conjugation types.

AXL Antibody
E306043 200ul
EUR 275
Description: Available in various conjugation types.

AXL Antibody
AF6824-100ul 100ul
EUR 280

AXL Antibody
AF6824-200ul 200ul
EUR 350

AXL Antibody
AF7793-100ul 100ul
EUR 350

AXL Antibody
AF7793-200ul 200ul
EUR 450

AXL Antibody
AF7793-50ul 50ul
EUR 250

AXL Antibody
AF8412-100ul 100ul
EUR 350

AXL Antibody
AF8412-200ul 200ul
EUR 450

AXL Antibody
AF8412-50ul 50ul
EUR 250

AXL Antibody
BF0290-100ul 100ul
EUR 350

AXL Antibody
BF0290-200ul 200ul
EUR 450

AXL Antibody
BF0290-50ul 50ul
EUR 250

AXL Antibody
AF6824 100ul
EUR 280
Description: Human,Mouse,Rat

AXL Antibody
AF7793 100ul
EUR 350
Description: Human,Mouse,Rat

AXL Antibody
AF8412 100ul
EUR 350
Description: Human,Mouse,Rat

AXL Antibody
BF0290 100ul
EUR 350
Description: Human

AXL Antibody
E10-20250 100μg/100μl
EUR 225
Description: Available in various conjugation types.

AXL Antibody
E10-20332 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Axl Antibody
E300616 100ug
EUR 275
Description: Available in various conjugation types.

AXL Antibody
CAC11246-100ug 100ug
EUR 314

AXL Antibody
CAC11246-50ug 50ug
EUR 199.2

Rabbit Anti-Mouse AXL protein IgG-Biotinylated
AXL11-BTN 100 ul
EUR 634.8

Axl Protein Vector (Mouse) (pPM-C-HA)
PV157852 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPM-C-HA)
PV157856 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPM-C-HA)
PV157860 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPB-C-His)
PV157850 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPB-N-His)
PV157851 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPM-C-His)
PV157853 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPB-C-His)
PV157854 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPB-N-His)
PV157855 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPM-C-His)
PV157857 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPB-C-His)
PV157858 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPB-N-His)
PV157859 500 ng
EUR 1278

Axl Protein Vector (Mouse) (pPM-C-His)
PV157861 500 ng
EUR 1278

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody
CAU21502-100ul 100ul
EUR 281.3

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody
CAU21502-200ul 200ul
EUR 351.1

Rabbit Anti-Mouse AXL protein IgG, aff pure
AXL11-A 100 ul
EUR 578.4

Axl sgRNA CRISPR Lentivector (Mouse) (Target 1)
K4394002 1.0 ug DNA
EUR 184.8

Axl sgRNA CRISPR Lentivector (Mouse) (Target 2)
K4394003 1.0 ug DNA
EUR 184.8

Axl sgRNA CRISPR Lentivector (Mouse) (Target 3)
K4394004 1.0 ug DNA
EUR 184.8

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat)
4-PAL230Ra01
  • EUR 330.00
  • EUR 3549.60
  • EUR 872.40
  • EUR 420.00
  • EUR 271.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL)

Recombinant AXL Receptor Tyrosine Kinase (AXL)
4-RPL230Hu01
  • EUR 569.44
  • EUR 276.00
  • EUR 1805.38
  • EUR 681.79
  • EUR 1243.58
  • EUR 456.00
  • EUR 4333.44
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human AXL Receptor Tyrosine Kinase expressed in: E.coli

Recombinant AXL Receptor Tyrosine Kinase (AXL)
4-RPL230Ra01
  • EUR 614.59
  • EUR 288.00
  • EUR 1974.72
  • EUR 738.24
  • EUR 1356.48
  • EUR 487.20
  • EUR 4756.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat AXL Receptor Tyrosine Kinase expressed in: E.coli

Recombinant AXL Receptor Tyrosine Kinase (AXL)
RPU54005-100ug 100ug
EUR 566.5

Recombinant AXL Receptor Tyrosine Kinase (AXL)
RPU54005-1mg 1mg
EUR 2511.6

Recombinant AXL Receptor Tyrosine Kinase (AXL)
RPU54005-50ug 50ug
EUR 455.4

Recombinant AXL Receptor Tyrosine Kinase (AXL)
RPU56028-100ug 100ug
EUR 514.8

Recombinant AXL Receptor Tyrosine Kinase (AXL)
RPU56028-1mg 1mg
EUR 2607.8

Recombinant AXL Receptor Tyrosine Kinase (AXL)
RPU56028-50ug 50ug
EUR 401.3

AXL (pY691) Antibody
20-abx249424
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

AXL (pY691) Antibody
abx148474-100ug 100 ug
EUR 526.8

AXL (pY702) Antibody
abx148475-100ug 100 ug
EUR 526.8

AXL (pT697) Antibody
20-abx009871
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

anti-AXL
YF-PA10419 50 ul
EUR 435.6
Description: Mouse polyclonal to AXL

anti-AXL
YF-PA10420 50 ug
EUR 435.6
Description: Mouse polyclonal to AXL

anti-AXL
YF-PA10421 100 ug
EUR 483.6
Description: Rabbit polyclonal to AXL

anti-AXL
YF-PA23279 50 ul
EUR 400.8
Description: Mouse polyclonal to AXL

anti-AXL
YF-PA27171 100 ul
EUR 483.6
Description: Rabbit polyclonal to AXL

AXL antibody (Tyr691)
70R-32634 100 ug
EUR 392.4
Description: Rabbit polyclonal AXL antibody (Tyr691)

AXL siRNA
20-abx908739
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

AXL siRNA
20-abx908740
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

Polyclonal AXL Antibody
APR05948G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AXL . This antibody is tested and proven to work in the following applications:

AXL Conjugated Antibody
C48205 100ul
EUR 476.4

Axl Polyclonal Antibody
ABP55772-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y697

Axl Polyclonal Antibody
ABP55772-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y697

Axl Polyclonal Antibody
ABP55772-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y697

Axl Polyclonal Antibody
ABP57379-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y691

Axl Polyclonal Antibody
ABP57379-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y691

Axl Polyclonal Antibody
ABP57379-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y691

Axl Polyclonal Antibody
ES8372-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against Axl from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Axl Polyclonal Antibody
ES8372-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against Axl from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Axl Polyclonal Antibody
ES6771-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against Axl from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

Axl Polyclonal Antibody
ES6771-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against Axl from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

AXL Polyclonal Antibody
E917874 100ul
EUR 225
Description: Available in various conjugation types.

Axl Polyclonal Antibody
E20-75690 100ug
EUR 225
Description: Available in various conjugation types.

Axl Polyclonal Antibody
E20-70426 100ug
EUR 225
Description: Available in various conjugation types.

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), PE
4-PAL230Ra01-PE
  • EUR 396.00
  • EUR 3754.80
  • EUR 1046.40
  • EUR 504.00
  • EUR 252.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with PE.

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), APC
4-PAL230Ra01-APC
  • EUR 465.60
  • EUR 4664.40
  • EUR 1278.00
  • EUR 601.20
  • EUR 284.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with APC.

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), Cy3
4-PAL230Ra01-Cy3
  • EUR 571.20
  • EUR 6169.20
  • EUR 1654.80
  • EUR 751.20
  • EUR 330.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with Cy3.

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), HRP
4-PAL230Ra01-HRP
  • EUR 423.60
  • EUR 4062.00
  • EUR 1128.00
  • EUR 541.20
  • EUR 266.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with HRP.

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), FITC
4-PAL230Ra01-FITC
  • EUR 396.00
  • EUR 3754.80
  • EUR 1046.40
  • EUR 504.00
  • EUR 252.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with FITC.

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), Biotinylated
4-PAL230Ra01-Biotin
  • EUR 411.60
  • EUR 3489.60
  • EUR 1006.80
  • EUR 510.00
  • EUR 278.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with Biotin.

Mouse Axl/ Tyrosine-protein kinase receptor UFO ELISA Kit
E0154Mo 1 Kit
EUR 655.2

Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
SEL230Ra-10x96wellstestplate 10x96-wells test plate
EUR 6745.94
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat AXL Receptor Tyrosine Kinase (AXL) in serum, plasma and other biological fluids.

Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
SEL230Ra-1x48wellstestplate 1x48-wells test plate
EUR 660.72
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat AXL Receptor Tyrosine Kinase (AXL) in serum, plasma and other biological fluids.

Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
SEL230Ra-1x96wellstestplate 1x96-wells test plate
EUR 892.46
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat AXL Receptor Tyrosine Kinase (AXL) in serum, plasma and other biological fluids.

Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
SEL230Ra-5x96wellstestplate 5x96-wells test plate
EUR 3656.09
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat AXL Receptor Tyrosine Kinase (AXL) in serum, plasma and other biological fluids.

Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
4-SEL230Ra
  • EUR 6806.40
  • EUR 3596.40
  • EUR 892.80
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat AXL Receptor Tyrosine Kinase (AXL) in samples from Serum, plasma and other biological fluids. with no significant corss-reactivity with analogues from other species.

Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
EKN43766-48T 48T
EUR 452.34

Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
EKN43766-5x96T 5x96T
EUR 3069.45

Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
EKN43766-96T 96T
EUR 646.2

Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
EKU02655-48T 48T
EUR 663.74

Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
EKU02655-5x96T 5x96T
EUR 4503.95

Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
EKU02655-96T 96T
EUR 948.2

Rat AXL(AXL Receptor Tyrosine Kinase) ELISA Kit
ELK8078-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat AXL. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat AXL. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat AXL, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat AXL in the samples is then determined by comparing the OD of the samples to the standard curve.

Rat AXL(AXL Receptor Tyrosine Kinase) ELISA Kit
ELK8078-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat AXL. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat AXL. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Rat AXL, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat AXL in the samples is then determined by comparing the OD of the samples to the standard curve.

Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
SEL230Hu-10x96wellstestplate 10x96-wells test plate
EUR 6227.58
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human AXL Receptor Tyrosine Kinase (AXL) in serum, plasma, tissue homogenates and other biological fluids.

Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
SEL230Hu-1x48wellstestplate 1x48-wells test plate
EUR 618.04
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human AXL Receptor Tyrosine Kinase (AXL) in serum, plasma, tissue homogenates and other biological fluids.

Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
SEL230Hu-1x96wellstestplate 1x96-wells test plate
EUR 831.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human AXL Receptor Tyrosine Kinase (AXL) in serum, plasma, tissue homogenates and other biological fluids.

Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
SEL230Hu-5x96wellstestplate 5x96-wells test plate
EUR 3381.66
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human AXL Receptor Tyrosine Kinase (AXL) in serum, plasma, tissue homogenates and other biological fluids.

Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
4-SEL230Hu
  • EUR 6288.00
  • EUR 3322.80
  • EUR 831.60
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human AXL Receptor Tyrosine Kinase (AXL) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
EKN50415-48T 48T
EUR 380.31

Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
EKN50415-5x96T 5x96T
EUR 2580.68

Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
EKN50415-96T 96T
EUR 543.3

Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
EKU09304-48T 48T
EUR 610.82

Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
EKU09304-5x96T 5x96T
EUR 4144.85

Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
EKU09304-96T 96T
EUR 872.6

Human AXL(AXL Receptor Tyrosine Kinase) ELISA Kit
ELK7559-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human AXL. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human AXL. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human AXL, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human AXL in the samples is then determined by comparing the OD of the samples to the standard curve.

Human AXL(AXL Receptor Tyrosine Kinase) ELISA Kit
ELK7559-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human AXL. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human AXL. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human AXL, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human AXL in the samples is then determined by comparing the OD of the samples to the standard curve.

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), APC-Cy7
4-PAL230Ra01-APC-Cy7
  • EUR 788.40
  • EUR 9184.80
  • EUR 2413.20
  • EUR 1058.40
  • EUR 426.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with APC-Cy7.

Mouse Tyrosine- protein kinase receptor UFO, Axl ELISA KIT
ELI-07418m 96 Tests
EUR 1038

Mouse Tyrosine-Protein Kinase Receptor UFO (AXL) ELISA Kit
abx520098-96tests 96 tests
EUR 801.6

Mouse Tyrosine-protein kinase receptor UFO(AXL) ELISA Kit
CSB-EL002476MO-24T 1 plate of 24 wells
EUR 198
Description: Quantitative sandwich ELISA kit for measuring Mouse Tyrosine-protein kinase receptor UFO (AXL) in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Tyrosine-protein kinase receptor UFO(AXL) ELISA Kit
1-CSB-EL002476MO
  • EUR 843.60
  • EUR 5811.60
  • EUR 3084.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitative sandwich ELISA kit for measuring Mouse Tyrosine-protein kinase receptor UFO(AXL) in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Mouse Tyrosine-protein kinase receptor UFO(AXL) ELISA Kit
EKC42379-48T 48T
EUR 474.04

Mouse Tyrosine-protein kinase receptor UFO(AXL) ELISA Kit
EKC42379-5x96T 5x96T
EUR 3216.7

Mouse Tyrosine-protein kinase receptor UFO(AXL) ELISA Kit
EKC42379-96T 96T
EUR 677.2

Axl, GST-tag
40180 10 µg
EUR 355
Description: AXL (GenBank Accession No. NM_021913), a.a. 473-894 with N-terminal GST-tag, MW= 77 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

AXL (Phospho- Tyr691) Antibody
ABF8522 100 ug
EUR 525.6

AXL (Phospho- Tyr702) Antibody
ABF8523 100 ug
EUR 525.6

AXL Antibody, HRP conjugated
1-CSB-PA326981LB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against AXL. Recognizes AXL from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

Anti-AXL Antibody
A00226-2 100ug/vial
EUR 352.8

Anti-AXL antibody
PAab00754 100 ug
EUR 426

Anti-AXL Antibody
R1406-3 100ul
EUR 189
Description: The UFO family of receptor tyrosine kinases is comprised of subfamily members Rse (also designated Tyro3, Sky, Brt, Dtk, Etk2 and Tif), Axl (also designated UFO or ARK) and Mer (also designated Nyk or Eyk). Rse is expressed Preferentially in the adult brain with lower expression in other tissues. Axl is found at highest levels in heart and skeletal muscle. Mer has been identified as a tyrosine kinase is involved in the development of glioblastomas. It is expressed at highest levels in ovary, prostate , Lung and kidney. Gas6, a growth arrest specific gene, and the related anticoagulation factor Protein S, have been identified as ligands for the UFO family of receptors.

Anti-Axl Antibody
STJ500198 100 µg
EUR 571.2

Anti-AXL antibody
STJ119885 100 µl
EUR 332.4
Description: The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene.

Anti-Axl antibody
STJ97643 200 µl
EUR 236.4
Description: Rabbit polyclonal to Axl.

Anti-Axl antibody
STJ97856 100 µl
EUR 280.8
Description: Mouse monoclonal to Axl.

Anti-Axl antibody
STJ97857 100 µl
EUR 280.8
Description: Mouse monoclonal to Axl.

Anti-Axl antibody
STJ91791 200 µl
EUR 236.4
Description: Rabbit polyclonal to Axl.

Anti-AXL antibody
STJ22748 100 µl
EUR 332.4
Description: The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene.

We assume that this is actually a double oxidation mechanically different from the single oxidation is observed and that the high stress conditions support the oxidation mechanism of double (and double oxidation sensitive tryptophan residue) whereas the single oxidation appears to be the main mode of H2O2 oxidation under pressure and length of a term thermal stability and favors a different tryptophan residues are more prone to oxidation mechanism single.

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