Vedolizumab immunogenicity was assessed using an enzyme-linked immunosorbent assay (ELISA) with ~ 0.5 ug / mL drug disorders, which may underestimate the on-drug immunogenicity. We aimed to compare the results between ELISA and immunogenicity of a new drug-tolerant electrochemiluminescence (ECL) assay (and two versions of neutralizing tests, drug-sensitive to the drug-tolerant).
ECL assay drug tolerance is ~ 100 times higher than the ELISA (≥ 50 mg / mL vs 0.5 ug / mL to 500 ng / mL positive control), and the sensitivity of the test is <5 ng / mL for both tests. Vedolizumab immunogenicity rated at 2000 GEMINI 1 and 2 patients initially tested by ELISA and retested by the ECL assay. anti-drug antibodies (ADA) results in infusion-related reactions-and pharmacokinetic (PK) was examined using descriptive statistics and population PK analysis.
With the ECL assay, 6% (86/1427) of patients treated with vedolizumab as induction and maintenance therapy ADA-positive tested. Of these, 20 patients with persistent positive and 56 had a neutralizing antibody. By ELISA, 4% (56/1434) of this ADA-positive patients, 9 were constantly positive, and 33 have antibodies. Among 61 patients with infusion-related reactions, 6 (10%) is ADA-positive (2 continuous positive) by ECL assay. By ELISA, 3 (5%) both ADA-positive patients and constantly positive.
Partial results (96%) was similar in both tests. In a population PK models are updated, ADA-positive status is expected to increase linearly vedolizumab clearance by a factor of 1.10 (95% credible interval 1.03 to 1.17), consistent with previous reports. ADA impacts the safety and PK modeling generally remained consistently good using ELISA or ECL assay.
Antitumor effect of humanized anti-tissue factor antibody-drug conjugate in a model of peritoneal disseminated pancreatic cancer
tissue factor (TF) is an attractive target for cancer therapy due to excess in some kinds of malignancies. Additionally, TF has been reported to play a functional role both in the development of cancer and metastasis. Several groups have developed antibody-drug conjugate (ADC) to the TF to be used as a cancer treatment, and has demonstrated efficacy in subcutaneous xenograft models of conventional and patient-derived xenograft model.
However, no previous studies have investigated the effectiveness of anti-TF ADC model with advanced cancer. This study developed the original anti-human TF monoclonal antibody conjugated to monomethyl auristatin E, and evaluated its efficacy in vivo in a xenograft model of pancreatic cancer with peritoneal dissemination. An in vitro study showed that the anti-TF ADC has a strong binding affinity and cytotoxic activity against human pancreatic cancer cells highly expressed TF antigen.
Anti-TF ADC also show greater antitumor effect than the ADC control in the conventional subcutaneous xenograft models, with efficacy depends on TF expression in the tumor tissue. Furthermore, the anti-TF ADC significantly inhibited tumor growth in an orthotopic xenograft model, and extend the lifespan in a murine model of peritoneal dissemination. These results suggest that anti-TF ADC has the potential to be an effective treatment not only for the primary tumor, but also for those who disseminated widely. Therefore, it can be concluded that the ADC targeting TF may be a promising agent for the treatment of advanced pancreatic cancer.
Treatment of Antibody-Mediated Rejection After Kidney Transplant: Effects immunology, clinical response, and histologic findings
BACKGROUND antibody-mediated rejection (AMR) prize with clinical manifestations are diverse and may have a potential negative impact on graft function and survival. If not treated successfully, AMR can lead to a 20-30% loss of the graft after one year. Little is known about the efficacy of the treatment of the AMR, and the most appropriate treatment strategy has not been determined.
This study evaluated the effects of AMR treatment with plasmapheresis (PP) and intravenous immunoglobulin (IVIG) on renal function, the intensity of anti-HLA antibodies, and graft biopsy morphology. MATERIALS AND METHODS retrospective cohort study of this center including AMR kidney transplant recipients with biopsy treated with PP and / or IVIG. clinical findings, mean fluorescence intensity of donor-specific antibodies anti-HLA (DSA), and graft histology findings, classified according to the Park scored at the time of AMR and 6 and 12 months later, were evaluated.
Results Of the 42 patients who met the inclusion criteria, 38 (90.5%) received IVIG and 26 (61.9%) underwent PP. At AMR diagnosis, 36 (85.7%) patients had proteinuria, with an estimated glomerular filtration rate they remained stable during follow-up. During the first year, 8 (19.0%) patients experienced graft failure, but did not die with a functioning graft. The decline of class I panel reactive antibodies were observed 6 and 12 months after treatment AMR, with a significant reduction in the DSA-A and -B fluorescence intensity, but there is no change in the DSA-DQ. Graft biopsy showed a reduction in inflammation and score C4D, without any improvement in microvascular inflammation. CONCLUSION AMR reduce treatment related biopsy and serological markers AMR, but does not affect the DSA-DQ.
Tryptophan Oxidation of Monoclonal Antibody under Various Conditions Oxidative Stress: Preparation oxidative Specific Favor Unlike tryptophan residue
oxidation of tryptophan could play an important role in choosing a therapeutic monoclonal antibody for commercialization. Monoclonal antibodies that harbor very sensitive tryptophan residue is usually discarded in favor of antibodies oxidation resistance.
Tryptophan residue individual susceptibility to oxidation is usually evaluated through the forced degradation studies during the development process of molecules. We compared the results of some general forced degradation „stress test” for any tryptophan residues in the monoclonal antibody and found that the oxidation state of high stress consistently give different ratings across the tryptophan residue oxidative sensitivity of individuals compared with long-term thermal stability or low stress conditions. We then determined that this difference in ranking is largely due to an overabundance of double oxidation (ie detected as 32 Da) specific tryptophan residue under high stress conditions as compared to a single oxidation (ie 16 Da).
Axl (untagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 1, (10ug) |
MC222408 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Mouse AXL Antibody Pair Set |
ABPR-ZB130 |
Creative Diagnostics |
5 plates, 15 plates |
Ask for price |
Description: Quantitative determination of Mouse AXL |
Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 2 |
MR222556 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 3 |
MR222558 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 1 |
MR211073 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Axl (GFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl) transcript variant 2, (10ug) |
MG222556 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Axl (GFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl) transcript variant 3, (10ug) |
MG222558 |
Origene Technologies GmbH |
10 µg |
Ask for price |
anti- AXL antibody |
FNab00754 |
FN Test |
100µg |
EUR 606.3 |
|
Description: Antibody raised against AXL |
Mouse AXL ELISA Kit |
EK5264 |
SAB |
96 tests |
EUR 599 |
|
Mouse AXL ELISA Kit |
E28L0663 |
EnoGene |
96T |
EUR 666.67 |
Mouse AXL ELISA Kit |
LF-EK50868 |
Abfrontier |
1×96T |
EUR 777.6 |
Mouse AXL shRNA Plasmid |
20-abx973661 |
Abbexa |
-
Ask for price
-
Ask for price
|
|
|
Mouse Monoclonal Antibody to AXL |
MAB-606020332 |
Antagene |
0.1ml |
EUR 280 |
Mouse Monoclonal Antiobody to AXL |
MAB-606020250 |
Antagene |
0.1ml |
EUR 260 |
Mouse Monoclonal Anti-Human AXL protein IgG-Biotinylated |
AXL13-BTN |
Alpha Diagnostics |
100 ul |
EUR 634.8 |
Mouse Monoclonal Anti-Human AXL protein IgG, aff pure |
AXL13-M |
Alpha Diagnostics |
100 ul |
EUR 578.4 |
Lenti ORF clone of Axl (mGFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 2 |
MR222556L4 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti ORF clone of Axl (mGFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 3 |
MR222558L4 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti ORF clone of Axl (mGFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 1 |
MR211073L2 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti ORF clone of Axl (mGFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 1 |
MR211073L4 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Mouse AXL Protein, His Tag |
E40MOP1139 |
EnoGene |
20ug |
EUR 495 |
Mouse AXL PicoKine ELISA Kit |
EK0660 |
BosterBio |
96 wells |
EUR 510 |
Description: For quantitative detection of mouse AXL in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). |
Anti-Human Axl Antibody |
101-M222 |
ReliaTech |
100 µg |
EUR 399 |
Description: Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt), and Mer (human and mouse homologues of chicken cEyk) constitute a subfamily of the receptor tyrosine kinases. The extracellular domains of these proteins contain two Iglike motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. The human Axl cDNA encodes an 887 amino acid (aa) precursor that includes an 18 aa signal sequence, a 426 aa extracellular domain, a 21 aa transmembrane segment, and a 422 aa cytoplasmic domain. The extracellular domains of human and mouse Axl share 81% aa sequence identity. A short alternately spliced form of human Axl is distinguished by a 9 aa deletion in the extracellular juxtamembrane region. These receptors bind the vitamin K dependent protein growth arrest specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration, or the prevention of apoptosis. This family of tyrosine kinase receptors is involved in hematopoiesis, embryonic development, tumorigenesis, and regulation of testicular functions. |
Axl ORF Vector (Mouse) (pORF) |
ORF039463 |
ABM |
1.0 ug DNA |
EUR 607.2 |
Axl ORF Vector (Mouse) (pORF) |
ORF039464 |
ABM |
1.0 ug DNA |
EUR 607.2 |
Axl ORF Vector (Mouse) (pORF) |
ORF039465 |
ABM |
1.0 ug DNA |
EUR 607.2 |
Lenti ORF clone of Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 2 |
MR222556L3 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti ORF clone of Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 3 |
MR222558L3 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti ORF clone of Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 1 |
MR211073L1 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti ORF clone of Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 1 |
MR211073L3 |
Origene Technologies GmbH |
10 µg |
Ask for price |
AXL ELISA Kit (Mouse) (OKBB00412) |
OKBB00412 |
Aviva Systems Biology |
96 Wells |
EUR 606 |
Description: Description of target: Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene. The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. Axl is a chronic myelogenous leukemia-associated oncogene and also associated with colon cancer and melanoma. It is in close vicinity to the bcl3 oncogene, which is at 19q13.1-q13.2. The Axl gene is evolutionarily conserved between vertebrate species. This gene has two different alternatively spliced transcript variants.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL |
Mouse AXL Protein, Fc & His Tag |
E40MOP1138 |
EnoGene |
20ug |
EUR 495 |
Lenti ORF particles, Axl (GFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 2, 200ul, >10^7 TU/mL |
MR222556L4V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Lenti ORF particles, Axl (GFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 3, 200ul, >10^7 TU/mL |
MR222558L4V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Lenti ORF particles, Axl (GFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 1, 200ul, >10^7 TU/mL |
MR211073L2V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Lenti ORF particles, Axl (GFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 1, 200ul, >10^7 TU/mL |
MR211073L4V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Rabbit Anti-Mouse AXL protein IgG-Biotinylated |
AXL11-BTN |
Alpha Diagnostics |
100 ul |
EUR 634.8 |
Lenti ORF particles, Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 2, 200ul, >10^7 TU/mL |
MR222556L3V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Lenti ORF particles, Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 3, 200ul, >10^7 TU/mL |
MR222558L3V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Lenti ORF particles, Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 1, 200ul, >10^7 TU/mL |
MR211073L1V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Lenti ORF particles, Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 1, 200ul, >10^7 TU/mL |
MR211073L3V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Axl sgRNA CRISPR Lentivector set (Mouse) |
K4394001 |
ABM |
3 x 1.0 ug |
EUR 406.8 |
AXL antibody |
10R-1995 |
Fitzgerald |
100 ul |
EUR 374 |
|
Description: Mouse monoclonal AXL antibody |
AXL antibody |
10R-2051 |
Fitzgerald |
100 ul |
EUR 468 |
|
Description: Mouse monoclonal AXL antibody |
Axl Antibody |
39365-100ul |
SAB |
100ul |
EUR 468 |
AXL Antibody |
48205 |
SAB |
100ul |
EUR 429 |
AXL Antibody |
48205-100ul |
SAB |
100ul |
EUR 399.6 |
AXL Antibody |
48205-50ul |
SAB |
50ul |
EUR 286.8 |
AXL Antibody |
1-CSB-PA030245 |
Cusabio |
-
Ask for price
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Ask for price
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Description: A polyclonal antibody against AXL. Recognizes AXL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000 |
AXL Antibody |
E10-20250 |
EnoGene |
100μg/100μl |
EUR 225 |
Description: Available in various conjugation types. |
AXL Antibody |
E10-20332 |
EnoGene |
100μg/100μl |
EUR 225 |
Description: Available in various conjugation types. |
AXL Antibody |
F44438-0.08ML |
NSJ Bioreagents |
0.08 ml |
EUR 140.25 |
|
Description: AXL may function as a signal transducer between specific cell types of mesodermal origin. |
AXL Antibody |
F44438-0.4ML |
NSJ Bioreagents |
0.4 ml |
EUR 322.15 |
|
Description: AXL may function as a signal transducer between specific cell types of mesodermal origin. |
AXL Antibody |
F50552-0.08ML |
NSJ Bioreagents |
0.08 ml |
EUR 140.25 |
|
Description: AXL, a member of the AXL/UFO subfamily of Tyr protein kinases, may function as a signal transducer between specific cell types of mesodermal origin. This Type I membrane protein has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia. The protein contains 2 putative fibronectin type III domains and 2 putative immunoglobulin-like C2-type domains. |
AXL Antibody |
F50552-0.4ML |
NSJ Bioreagents |
0.4 ml |
EUR 322.15 |
|
Description: AXL, a member of the AXL/UFO subfamily of Tyr protein kinases, may function as a signal transducer between specific cell types of mesodermal origin. This Type I membrane protein has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia. The protein contains 2 putative fibronectin type III domains and 2 putative immunoglobulin-like C2-type domains. |
AXL Antibody |
F50553-0.08ML |
NSJ Bioreagents |
0.08 ml |
EUR 140.25 |
|
Description: AXL, a member of the AXL/UFO subfamily of Tyr protein kinases, may function as a signal transducer between specific cell types of mesodermal origin. This Type I membrane protein has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia. The protein contains 2 putative fibronectin type III domains and 2 putative immunoglobulin-like C2-type domains. |
AXL Antibody |
F50553-0.4ML |
NSJ Bioreagents |
0.4 ml |
EUR 322.15 |
|
Description: AXL, a member of the AXL/UFO subfamily of Tyr protein kinases, may function as a signal transducer between specific cell types of mesodermal origin. This Type I membrane protein has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia. The protein contains 2 putative fibronectin type III domains and 2 putative immunoglobulin-like C2-type domains. |
AXL Antibody |
F50554-0.08ML |
NSJ Bioreagents |
0.08 ml |
EUR 140.25 |
|
Description: GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. [UniProt] |
AXL Antibody |
F50554-0.4ML |
NSJ Bioreagents |
0.4 ml |
EUR 322.15 |
|
Description: GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. [UniProt] |
AXL Antibody |
E306043 |
EnoGene |
200ul |
EUR 275 |
Description: Available in various conjugation types. |
Axl Antibody |
E90532 |
EnoGene |
100ul |
EUR 255 |
Description: Available in various conjugation types. |
AXL Antibody |
F53357-0.08ML |
NSJ Bioreagents |
0.08 ml |
EUR 140.25 |
|
Description: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor. [UniProt] |
AXL Antibody |
F53357-0.4ML |
NSJ Bioreagents |
0.4 ml |
EUR 322.15 |
|
Description: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor. [UniProt] |
Axl Antibody |
E300616 |
EnoGene |
100ug |
EUR 275 |
Description: Available in various conjugation types. |
AXL Antibody |
E38PA5315 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
AXL antibody |
70R-9655 |
Fitzgerald |
50 ug |
EUR 467 |
|
Description: Affinity purified rabbit polyclonal AXL antibody |
AXL antibody |
70R-51253 |
Fitzgerald |
100 ul |
EUR 286 |
|
Description: Purified Polyclonal AXL antibody |
AXL Antibody |
1-CSB-PA297707 |
Cusabio |
-
Ask for price
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Description: A polyclonal antibody against AXL. Recognizes AXL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000 |
AXL Antibody |
1-CSB-PA326981LA01HU |
Cusabio |
-
Ask for price
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Ask for price
|
|
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Description: A polyclonal antibody against AXL. Recognizes AXL from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200 |
AXL Antibody |
RQ6041 |
NSJ Bioreagents |
100 ug |
EUR 356.15 |
|
Description: Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene. This gene is mapped to 19q13.2. The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. |
AXL |
E8R1406-3 |
EnoGene |
100ul |
EUR 275 |
Description: Available in various conjugation types. |
AXL |
CSB-CL326981HU |
Cusabio |
10 μg plasmid + 200μl Glycerol |
Ask for price |
Rabbit Anti-Mouse AXL protein IgG, aff pure |
AXL11-A |
Alpha Diagnostics |
100 ul |
EUR 578.4 |
Axl Protein Vector (Mouse) (pPM-C-HA) |
PV157852 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPM-C-HA) |
PV157856 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPM-C-HA) |
PV157860 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPB-C-His) |
PV157850 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPB-N-His) |
PV157851 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPM-C-His) |
PV157853 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPB-C-His) |
PV157854 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPB-N-His) |
PV157855 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPM-C-His) |
PV157857 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPB-C-His) |
PV157858 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPB-N-His) |
PV157859 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPM-C-His) |
PV157861 |
ABM |
500 ng |
EUR 1278 |
Mouse AXL Receptor Tyrosine Kinase ELISA kit |
E01A19041 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Recombinant Mouse Axl Kinase Protein (His Tag) |
PKSM040849-100ug |
Elabscience Biotech |
100ug |
EUR 732 |
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Description: Mouse |
AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody |
CAU21502-100ul |
Biomatik Corporation |
100ul |
EUR 281.3 |
AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody |
CAU21502-200ul |
Biomatik Corporation |
200ul |
EUR 351.1 |
Rabbit Anti-Mouse AXL monoclonal antibody, clone S210 |
CABT-ZB554 |
Creative Diagnostics |
50 μl |
EUR 520 |
|
Description: Rabbit |
Rabbit Anti-Mouse AXL monoclonal antibody, clone S126 |
CABT-ZB916 |
Creative Diagnostics |
50 μl |
EUR 520 |
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Description: Rabbit |
Axl sgRNA CRISPR Lentivector (Mouse) (Target 1) |
K4394002 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Axl sgRNA CRISPR Lentivector (Mouse) (Target 2) |
K4394003 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Axl sgRNA CRISPR Lentivector (Mouse) (Target 3) |
K4394004 |
ABM |
1.0 ug DNA |
EUR 184.8 |
anti-AXL |
YF-PA27171 |
Abfrontier |
100 ul |
EUR 483.6 |
Description: Rabbit polyclonal to AXL |
anti-AXL |
YF-PA10419 |
Abfrontier |
50 ul |
EUR 435.6 |
Description: Mouse polyclonal to AXL |
anti-AXL |
YF-PA10420 |
Abfrontier |
50 ug |
EUR 435.6 |
Description: Mouse polyclonal to AXL |
anti-AXL |
YF-PA10421 |
Abfrontier |
100 ug |
EUR 483.6 |
Description: Rabbit polyclonal to AXL |
anti-AXL |
YF-PA23279 |
Abfrontier |
50 ul |
EUR 400.8 |
Description: Mouse polyclonal to AXL |
Polyclonal Antibody to AXL Receptor Tyrosine Kinase (AXL) |
PAL230Ra01 |
Cloud-Clone |
100ul |
EUR 293 |
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AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat) |
4-PAL230Ra01 |
Cloud-Clone |
-
Ask for price
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-
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-
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|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
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Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL) |
Recombinant Mouse Axl Kinase Protein (His & Fc Tag) |
PKSM040850-100ug |
Elabscience Biotech |
100ug |
EUR 732 |
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Description: Mouse |
Recombinant AXL Receptor Tyrosine Kinase (AXL) |
RPL230Hu01 |
Cloud-Clone |
10ug |
EUR 167 |
Recombinant AXL Receptor Tyrosine Kinase (AXL) |
4-RPL230Hu01 |
Cloud-Clone |
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- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
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Description: Recombinant Human AXL Receptor Tyrosine Kinase expressed in: E.coli |
Recombinant AXL Receptor Tyrosine Kinase (AXL) |
RPL230Ra01 |
Cloud-Clone |
10ug |
EUR 184 |
Recombinant AXL Receptor Tyrosine Kinase (AXL) |
4-RPL230Ra01 |
Cloud-Clone |
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|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
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Description: Recombinant Rat AXL Receptor Tyrosine Kinase expressed in: E.coli |
AXL (untagged)-Human AXL receptor tyrosine kinase (AXL), transcript variant 1 |
SC112559 |
Origene Technologies GmbH |
10 µg |
Ask for price |
AXL (untagged)-Human AXL receptor tyrosine kinase (AXL), transcript variant 2 |
SC125242 |
Origene Technologies GmbH |
10 µg |
Ask for price |
AXL (untagged) - Human AXL receptor tyrosine kinase (AXL), transcript variant 3 |
SC337032 |
Origene Technologies GmbH |
10 µg |
Ask for price |
AXL (pY691) Antibody |
20-abx249424 |
Abbexa |
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- 100 ug
- 10 ug
- 200 ug
- 300 µg
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AXL (pY691) Antibody |
abx148474-100ug |
Abbexa |
100 ug |
EUR 526.8 |
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AXL (pY702) Antibody |
abx148475-100ug |
Abbexa |
100 ug |
EUR 526.8 |
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AXL (pT697) Antibody |
20-abx009871 |
Abbexa |
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AXL (pY691) Antibody |
abx249424-96tests |
Abbexa |
96 tests |
EUR 43.75 |
AXL antibody (Tyr691) |
70R-32634 |
Fitzgerald |
100 ug |
EUR 294 |
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Description: Rabbit polyclonal AXL antibody (Tyr691) |
AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), PE |
4-PAL230Ra01-PE |
Cloud-Clone |
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- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
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Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with PE. |
AXL siRNA |
20-abx908739 |
Abbexa |
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AXL siRNA |
20-abx908740 |
Abbexa |
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AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), APC |
4-PAL230Ra01-APC |
Cloud-Clone |
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|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
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Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with APC. |
AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), Cy3 |
4-PAL230Ra01-Cy3 |
Cloud-Clone |
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|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with Cy3. |
AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), HRP |
4-PAL230Ra01-HRP |
Cloud-Clone |
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|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with HRP. |
AXL Polyclonal Antibody |
E917874 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Axl Polyclonal Antibody |
E20-70426 |
EnoGene |
100ug |
EUR 225 |
Description: Available in various conjugation types. |
Axl Polyclonal Antibody |
E20-75690 |
EnoGene |
100ug |
EUR 225 |
Description: Available in various conjugation types. |
Polyclonal AXL Antibody |
APR05948G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AXL . This antibody is tested and proven to work in the following applications: |
AXL Conjugated Antibody |
C48205 |
SAB |
100ul |
EUR 476.4 |
Axl Polyclonal Antibody |
ABP57379-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
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Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y691 |
Axl Polyclonal Antibody |
ABP57379-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
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Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y691 |
Axl Polyclonal Antibody |
ABP57379-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
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Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y691 |
Axl Polyclonal Antibody |
ABP55772-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
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Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y697 |
Axl Polyclonal Antibody |
ABP55772-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
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Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y697 |
Axl Polyclonal Antibody |
ABP55772-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
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Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y697 |
We assume that this is actually a double oxidation mechanically different from the single oxidation is observed and that the high stress conditions support the oxidation mechanism of double (and double oxidation sensitive tryptophan residue) whereas the single oxidation appears to be the main mode of H2O2 oxidation under pressure and length of a term thermal stability and favors a different tryptophan residues are more prone to oxidation mechanism single.