Vedolizumab immunogenicity was assessed using an enzyme-linked immunosorbent assay (ELISA) with ~ 0.5 ug / mL drug disorders, which may underestimate the on-drug immunogenicity. We aimed to compare the results between ELISA and immunogenicity of a new drug-tolerant electrochemiluminescence (ECL) assay (and two versions of neutralizing tests, drug-sensitive to the drug-tolerant).
ECL assay drug tolerance is ~ 100 times higher than the ELISA (≥ 50 mg / mL vs 0.5 ug / mL to 500 ng / mL positive control), and the sensitivity of the test is <5 ng / mL for both tests. Vedolizumab immunogenicity rated at 2000 GEMINI 1 and 2 patients initially tested by ELISA and retested by the ECL assay. anti-drug antibodies (ADA) results in infusion-related reactions-and pharmacokinetic (PK) was examined using descriptive statistics and population PK analysis.
With the ECL assay, 6% (86/1427) of patients treated with vedolizumab as induction and maintenance therapy ADA-positive tested. Of these, 20 patients with persistent positive and 56 had a neutralizing antibody. By ELISA, 4% (56/1434) of this ADA-positive patients, 9 were constantly positive, and 33 have antibodies. Among 61 patients with infusion-related reactions, 6 (10%) is ADA-positive (2 continuous positive) by ECL assay. By ELISA, 3 (5%) both ADA-positive patients and constantly positive.
Partial results (96%) was similar in both tests. In a population PK models are updated, ADA-positive status is expected to increase linearly vedolizumab clearance by a factor of 1.10 (95% credible interval 1.03 to 1.17), consistent with previous reports. ADA impacts the safety and PK modeling generally remained consistently good using ELISA or ECL assay.
Antitumor effect of humanized anti-tissue factor antibody-drug conjugate in a model of peritoneal disseminated pancreatic cancer
tissue factor (TF) is an attractive target for cancer therapy due to excess in some kinds of malignancies. Additionally, TF has been reported to play a functional role both in the development of cancer and metastasis. Several groups have developed antibody-drug conjugate (ADC) to the TF to be used as a cancer treatment, and has demonstrated efficacy in subcutaneous xenograft models of conventional and patient-derived xenograft model.
However, no previous studies have investigated the effectiveness of anti-TF ADC model with advanced cancer. This study developed the original anti-human TF monoclonal antibody conjugated to monomethyl auristatin E, and evaluated its efficacy in vivo in a xenograft model of pancreatic cancer with peritoneal dissemination. An in vitro study showed that the anti-TF ADC has a strong binding affinity and cytotoxic activity against human pancreatic cancer cells highly expressed TF antigen.
Anti-TF ADC also show greater antitumor effect than the ADC control in the conventional subcutaneous xenograft models, with efficacy depends on TF expression in the tumor tissue. Furthermore, the anti-TF ADC significantly inhibited tumor growth in an orthotopic xenograft model, and extend the lifespan in a murine model of peritoneal dissemination. These results suggest that anti-TF ADC has the potential to be an effective treatment not only for the primary tumor, but also for those who disseminated widely. Therefore, it can be concluded that the ADC targeting TF may be a promising agent for the treatment of advanced pancreatic cancer.
Treatment of Antibody-Mediated Rejection After Kidney Transplant: Effects immunology, clinical response, and histologic findings
BACKGROUND antibody-mediated rejection (AMR) prize with clinical manifestations are diverse and may have a potential negative impact on graft function and survival. If not treated successfully, AMR can lead to a 20-30% loss of the graft after one year. Little is known about the efficacy of the treatment of the AMR, and the most appropriate treatment strategy has not been determined.
This study evaluated the effects of AMR treatment with plasmapheresis (PP) and intravenous immunoglobulin (IVIG) on renal function, the intensity of anti-HLA antibodies, and graft biopsy morphology. MATERIALS AND METHODS retrospective cohort study of this center including AMR kidney transplant recipients with biopsy treated with PP and / or IVIG. clinical findings, mean fluorescence intensity of donor-specific antibodies anti-HLA (DSA), and graft histology findings, classified according to the Park scored at the time of AMR and 6 and 12 months later, were evaluated.
Results Of the 42 patients who met the inclusion criteria, 38 (90.5%) received IVIG and 26 (61.9%) underwent PP. At AMR diagnosis, 36 (85.7%) patients had proteinuria, with an estimated glomerular filtration rate they remained stable during follow-up. During the first year, 8 (19.0%) patients experienced graft failure, but did not die with a functioning graft. The decline of class I panel reactive antibodies were observed 6 and 12 months after treatment AMR, with a significant reduction in the DSA-A and -B fluorescence intensity, but there is no change in the DSA-DQ. Graft biopsy showed a reduction in inflammation and score C4D, without any improvement in microvascular inflammation. CONCLUSION AMR reduce treatment related biopsy and serological markers AMR, but does not affect the DSA-DQ.
Tryptophan Oxidation of Monoclonal Antibody under Various Conditions Oxidative Stress: Preparation oxidative Specific Favor Unlike tryptophan residue
oxidation of tryptophan could play an important role in choosing a therapeutic monoclonal antibody for commercialization. Monoclonal antibodies that harbor very sensitive tryptophan residue is usually discarded in favor of antibodies oxidation resistance.

Tryptophan residue individual susceptibility to oxidation is usually evaluated through the forced degradation studies during the development process of molecules. We compared the results of some general forced degradation „stress test” for any tryptophan residues in the monoclonal antibody and found that the oxidation state of high stress consistently give different ratings across the tryptophan residue oxidative sensitivity of individuals compared with long-term thermal stability or low stress conditions. We then determined that this difference in ranking is largely due to an overabundance of double oxidation (ie detected as 32 Da) specific tryptophan residue under high stress conditions as compared to a single oxidation (ie 16 Da).
anti-AXL (7E10) |
LF-MA30273 |
Abfrontier |
100 ul |
EUR 583.2 |
Description: Mouse Monoclonal to AXL |
anti- AXL antibody |
FNab00754 |
FN Test |
100µg |
EUR 606.3 |
|
Description: Antibody raised against AXL |
Anti-Axl antibody |
STJ91791 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Rabbit polyclonal to Axl. |
Anti-Axl antibody |
STJ97643 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Rabbit polyclonal to Axl. |
Anti-Axl antibody |
STJ97856 |
St John's Laboratory |
100 µl |
EUR 280.8 |
Description: Mouse monoclonal to Axl. |
Anti-Axl antibody |
STJ97857 |
St John's Laboratory |
100 µl |
EUR 280.8 |
Description: Mouse monoclonal to Axl. |
Anti-AXL antibody |
STJ119885 |
St John's Laboratory |
100 µl |
EUR 332.4 |
Description: The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. |
Anti-AXL antibody |
STJ22748 |
St John's Laboratory |
100 µl |
EUR 332.4 |
Description: The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. |
Anti-AXL (6C8) |
YF-MA10084 |
Abfrontier |
100 ug |
EUR 435.6 |
Description: Mouse monoclonal to AXL |
Anti-AXL (6G1) |
YF-MA10085 |
Abfrontier |
100 ug |
EUR 435.6 |
Description: Mouse monoclonal to AXL |
Anti-Axl (2C10) |
YF-MA12092 |
Abfrontier |
100 ug |
EUR 435.6 |
Description: Mouse monoclonal to Axl |
Rabbit Polyclonal antibody Anti-CRBN |
Anti-CRBN |
ImmunoStep |
50 µg |
EUR 418.8 |
Rabbit Anti-Mouse AXL protein IgG-Biotinylated |
AXL11-BTN |
Alpha Diagnostics |
100 ul |
EUR 634.8 |
Mouse AXL shRNA Plasmid |
20-abx973661 |
Abbexa |
|
|
|
Mouse AXL ELISA Kit |
LF-EK50868 |
Abfrontier |
1×96T |
EUR 777.6 |
Polyclonal Rabbit Anti-AXL antibody |
APR05486G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Rabbit Anti-AXL . This antibody is tested and proven to work in the following applications: |
Anti-Phospho-AXL-Y702 antibody |
STJ11100989 |
St John's Laboratory |
100 µl |
EUR 471.6 |
Description: The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. |
Anti-Phospho-Axl (Y691) antibody |
STJ90939 |
St John's Laboratory |
200 µl |
EUR 236.4 |
Description: Axl is a protein encoded by the AXL gene which is approximately 98,3 kDa. Axl is localised to the cell membrane. It is involved in the GPCR pathway, ERK signalling, actin nucleation by ARP-WASP complex and activation of cAMP-dependent PKA. This protein falls under the Tyro3-Axl-Mer receptor tyrosine kinase subfamily. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6. Axl is expressed in primary colon tumors but weakly expressed in normal colon tissue. Mutations in the AXL gene may result in lymphocytic choriomeningitis, femoral neuropathy and Borna disease. STJ90939 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Axl protein which only binds about Y691 when Y691 is phosphorylated. |
Recombinant AXL Receptor Tyrosine Kinase (AXL) |
4-RPL230Hu01 |
Cloud-Clone |
-
EUR 569.44
-
EUR 276.00
-
EUR 1805.38
-
EUR 681.79
-
EUR 1243.58
-
EUR 456.00
-
EUR 4333.44
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
Description: Recombinant Human AXL Receptor Tyrosine Kinase expressed in: E.coli |
Recombinant AXL Receptor Tyrosine Kinase (AXL) |
4-RPL230Ra01 |
Cloud-Clone |
-
EUR 614.59
-
EUR 288.00
-
EUR 1974.72
-
EUR 738.24
-
EUR 1356.48
-
EUR 487.20
-
EUR 4756.80
|
- 100 ug
- 10ug
- 1 mg
- 200 ug
- 500 ug
- 50ug
- 5 mg
|
|
Description: Recombinant Rat AXL Receptor Tyrosine Kinase expressed in: E.coli |
AXL antibody |
70R-51253 |
Fitzgerald |
100 ul |
EUR 344.4 |
Description: Purified Polyclonal AXL antibody |
Axl Antibody |
39365-100ul |
SAB |
100ul |
EUR 468 |
AXL Antibody |
48205-100ul |
SAB |
100ul |
EUR 399.6 |
AXL Antibody |
48205-50ul |
SAB |
50ul |
EUR 286.8 |
AXL antibody |
10R-1995 |
Fitzgerald |
100 ul |
EUR 392.4 |
Description: Mouse monoclonal AXL antibody |
AXL antibody |
10R-2051 |
Fitzgerald |
100 ul |
EUR 483.6 |
Description: Mouse monoclonal AXL antibody |
AXL antibody |
70R-9655 |
Fitzgerald |
50 ug |
EUR 560.4 |
Description: Affinity purified rabbit polyclonal AXL antibody |
AXL Antibody |
1-CSB-PA030245 |
Cusabio |
|
|
|
Description: A polyclonal antibody against AXL. Recognizes AXL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000 |
AXL Antibody |
1-CSB-PA297707 |
Cusabio |
|
|
|
Description: A polyclonal antibody against AXL. Recognizes AXL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000 |
AXL Antibody |
1-CSB-PA326981LA01HU |
Cusabio |
|
|
|
Description: A polyclonal antibody against AXL. Recognizes AXL from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200 |
AXL Antibody |
RQ6041 |
NSJ Bioreagents |
100 ug |
EUR 419 |
Description: Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene. This gene is mapped to 19q13.2. The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. |
Rabbit Anti-Mouse AXL protein IgG, aff pure |
AXL11-A |
Alpha Diagnostics |
100 ul |
EUR 578.4 |
Mouse Monoclonal Anti-Human AXL protein IgG-Biotinylated |
AXL13-BTN |
Alpha Diagnostics |
100 ul |
EUR 634.8 |
Polyclonal Goat anti-GST α-form |
GST-ANTI-1 |
Detroit R&D |
50 uL |
EUR 336 |
Polyclonal Goat anti-GST μ-form |
GST-ANTI-2 |
Detroit R&D |
50 uL |
EUR 336 |
Polyclonal Goat anti-GST p-form |
GST-ANTI-3 |
Detroit R&D |
50 uL |
EUR 336 |
AXL ELISA Kit (Mouse) (OKBB00412) |
OKBB00412 |
Aviva Systems Biology |
96 Wells |
EUR 606 |
Description: Description of target: Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene. The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. Axl is a chronic myelogenous leukemia-associated oncogene and also associated with colon cancer and melanoma. It is in close vicinity to the bcl3 oncogene, which is at 19q13.1-q13.2. The Axl gene is evolutionarily conserved between vertebrate species. This gene has two different alternatively spliced transcript variants.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL |
Mouse AXL PicoKine ELISA Kit |
EK0660 |
BosterBio |
96 wells |
EUR 510 |
Description: For quantitative detection of mouse AXL in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). |
Axl ORF Vector (Mouse) (pORF) |
ORF039463 |
ABM |
1.0 ug DNA |
EUR 607.2 |
Axl ORF Vector (Mouse) (pORF) |
ORF039464 |
ABM |
1.0 ug DNA |
EUR 607.2 |
Axl ORF Vector (Mouse) (pORF) |
ORF039465 |
ABM |
1.0 ug DNA |
EUR 607.2 |
ELISA kit for Mouse AXL |
EK5264 |
SAB |
96 tests |
EUR 663.6 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse AXL in samples from serum, plasma, tissue homogenates and other biological fluids. |
Mouse Monoclonal Anti-Human AXL protein IgG, aff pure |
AXL13-M |
Alpha Diagnostics |
100 ul |
EUR 578.4 |
AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat) |
4-PAL230Ra01 |
Cloud-Clone |
-
EUR 330.00
-
EUR 3549.60
-
EUR 872.40
-
EUR 420.00
-
EUR 271.20
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL) |
Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit |
SEL230Hu-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 6227.58 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human AXL Receptor Tyrosine Kinase (AXL) in serum, plasma, tissue homogenates and other biological fluids. |
Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit |
SEL230Hu-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 618.04 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human AXL Receptor Tyrosine Kinase (AXL) in serum, plasma, tissue homogenates and other biological fluids. |
Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit |
SEL230Hu-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 831.48 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human AXL Receptor Tyrosine Kinase (AXL) in serum, plasma, tissue homogenates and other biological fluids. |
Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit |
SEL230Hu-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 3381.66 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human AXL Receptor Tyrosine Kinase (AXL) in serum, plasma, tissue homogenates and other biological fluids. |
Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit |
4-SEL230Hu |
Cloud-Clone |
-
EUR 6288.00
-
EUR 3322.80
-
EUR 831.60
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human AXL Receptor Tyrosine Kinase (AXL) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. |
Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit |
SEL230Ra-10x96wellstestplate |
Cloud-Clone |
10x96-wells test plate |
EUR 6745.94 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat AXL Receptor Tyrosine Kinase (AXL) in serum, plasma and other biological fluids. |
Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit |
SEL230Ra-1x48wellstestplate |
Cloud-Clone |
1x48-wells test plate |
EUR 660.72 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat AXL Receptor Tyrosine Kinase (AXL) in serum, plasma and other biological fluids. |
Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit |
SEL230Ra-1x96wellstestplate |
Cloud-Clone |
1x96-wells test plate |
EUR 892.46 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat AXL Receptor Tyrosine Kinase (AXL) in serum, plasma and other biological fluids. |
Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit |
SEL230Ra-5x96wellstestplate |
Cloud-Clone |
5x96-wells test plate |
EUR 3656.09 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat AXL Receptor Tyrosine Kinase (AXL) in serum, plasma and other biological fluids. |
Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit |
4-SEL230Ra |
Cloud-Clone |
-
EUR 6806.40
-
EUR 3596.40
-
EUR 892.80
|
- 10 plates of 96 wells
- 5 plates of 96 wells
- 1 plate of 96 wells
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat AXL Receptor Tyrosine Kinase (AXL) in samples from Serum, plasma and other biological fluids. with no significant corss-reactivity with analogues from other species. |
AXL Rabbit pAb |
A0532-100ul |
Abclonal |
100 ul |
EUR 369.6 |
AXL Rabbit pAb |
A0532-200ul |
Abclonal |
200 ul |
EUR 550.8 |
AXL Rabbit pAb |
A0532-20ul |
Abclonal |
20 ul |
Ask for price |
AXL Rabbit pAb |
A0532-50ul |
Abclonal |
50 ul |
Ask for price |
AXL antibody (Tyr691) |
70R-32634 |
Fitzgerald |
100 ug |
EUR 392.4 |
Description: Rabbit polyclonal AXL antibody (Tyr691) |
AXL Blocking Peptide |
33R-7673 |
Fitzgerald |
100 ug |
EUR 216 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of AXL antibody, catalog no. 70R-9655 |
Axl Recombinant Protein |
11-290 |
ProSci |
0.1 mg |
EUR 651.3 |
Description: AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL contains two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. AXL is highly expressed in metastatic colon tumors. AXL is activated by GAS6-binding and subsequent autophosphorylation. AXL is involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation. |
Axl Polyclonal Antibody |
ABP55772-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y697 |
Axl Polyclonal Antibody |
ABP55772-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y697 |
Axl Polyclonal Antibody |
ABP55772-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y697 |
AXL (pY691) Antibody |
abx148474-100ug |
Abbexa |
100 ug |
EUR 526.8 |
|
AXL (pY702) Antibody |
abx148475-100ug |
Abbexa |
100 ug |
EUR 526.8 |
|
Axl Polyclonal Antibody |
ABP57379-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y691 |
Axl Polyclonal Antibody |
ABP57379-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y691 |
Axl Polyclonal Antibody |
ABP57379-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y691 |
AXL Blocking Peptide |
20-abx061788 |
Abbexa |
|
|
|
AXL (pT697) Antibody |
20-abx009871 |
Abbexa |
-
EUR 376.80
-
EUR 560.40
-
EUR 243.60
|
|
|
AXL Rabbit pAb |
A17874-100ul |
Abclonal |
100 ul |
EUR 369.6 |
AXL Rabbit pAb |
A17874-200ul |
Abclonal |
200 ul |
EUR 550.8 |
AXL Rabbit pAb |
A17874-20ul |
Abclonal |
20 ul |
EUR 219.6 |
AXL Rabbit pAb |
A17874-50ul |
Abclonal |
50 ul |
EUR 267.6 |
AXL (pY691) Antibody |
20-abx249424 |
Abbexa |
-
EUR 376.80
-
EUR 117.60
-
EUR 477.60
-
EUR 594.00
|
- 100 ug
- 10 ug
- 200 ug
- 300 µg
|
|
AXL Recombinant Protein |
96-037 |
ProSci |
0.2 mg |
EUR 588.3 |
Description: AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL contains two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. AXL is highly expressed in metastatic colon tumors. AXL is activated by GAS6-binding and subsequent autophosphorylation. AXL is involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation. |
Polyclonal AXL Antibody |
APR05948G |
Leading Biology |
0.1ml |
EUR 580.8 |
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AXL . This antibody is tested and proven to work in the following applications: |
AXL Blocking Peptide |
AF7793-BP |
Affbiotech |
1mg |
EUR 234 |
AXL Blocking Peptide |
AF8412-BP |
Affbiotech |
1mg |
EUR 234 |
AXL Blocking Peptide |
BF0290-BP |
Affbiotech |
1mg |
EUR 234 |
AXL Conjugated Antibody |
C48205 |
SAB |
100ul |
EUR 476.4 |
AXL cloning plasmid |
CSB-CL326981HU-10ug |
Cusabio |
10ug |
EUR 1033.2 |
|
Description: A cloning plasmid for the AXL gene. |
Axl Polyclonal Antibody |
ES8372-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against Axl from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
Axl Polyclonal Antibody |
ES8372-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against Axl from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA |
Axl Polyclonal Antibody |
ES6771-100ul |
ELK Biotech |
100ul |
EUR 334.8 |
Description: A Rabbit Polyclonal antibody against Axl from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA |
Axl Polyclonal Antibody |
ES6771-50ul |
ELK Biotech |
50ul |
EUR 248.4 |
Description: A Rabbit Polyclonal antibody against Axl from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA |
AXL, FLAG-Tag |
100174 |
BPS Bioscience |
10 µg |
EUR 355 |
Description: Human AXL, also known as Tyrosine-protein kinase receptor UFO, and JTK11, GenBank Accession No. NM_021913, a.a. 473-894 (end) with N-terminal FLAG-Tag, MW= 49 kDa, expressed in a Baculovirus infected Sf9 cell expression system. |
Axl, GST-tag |
40180 |
BPS Bioscience |
10 µg |
EUR 355 |
Description: AXL (GenBank Accession No. NM_021913), a.a. 473-894 with N-terminal GST-tag, MW= 77 kDa, expressed in a Baculovirus infected Sf9 cell expression system. |
Rabbit Anti-Human AXL protein IgG-Biotinylated |
AXL12-BTN |
Alpha Diagnostics |
100 ul |
EUR 634.8 |
Axl sgRNA CRISPR Lentivector set (Mouse) |
K4394001 |
ABM |
3 x 1.0 ug |
EUR 406.8 |
ELISA kit for Human AXL (AXL Receptor Tyrosine Kinase) |
ELK7559 |
ELK Biotech |
1 plate of 96 wells |
EUR 518.4 |
|
Description: A sandwich ELISA kit for detection of AXL Receptor Tyrosine Kinase from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
ELISA kit for Rat AXL (AXL Receptor Tyrosine Kinase) |
ELK8078 |
ELK Biotech |
1 plate of 96 wells |
EUR 518.4 |
|
Description: A sandwich ELISA kit for detection of AXL Receptor Tyrosine Kinase from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), APC |
4-PAL230Ra01-APC |
Cloud-Clone |
-
EUR 465.60
-
EUR 4664.40
-
EUR 1278.00
-
EUR 601.20
-
EUR 284.40
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with APC. |
AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), Biotinylated |
4-PAL230Ra01-Biotin |
Cloud-Clone |
-
EUR 411.60
-
EUR 3489.60
-
EUR 1006.80
-
EUR 510.00
-
EUR 278.40
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with Biotin. |
AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), Cy3 |
4-PAL230Ra01-Cy3 |
Cloud-Clone |
-
EUR 571.20
-
EUR 6169.20
-
EUR 1654.80
-
EUR 751.20
-
EUR 330.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with Cy3. |
AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), FITC |
4-PAL230Ra01-FITC |
Cloud-Clone |
-
EUR 396.00
-
EUR 3754.80
-
EUR 1046.40
-
EUR 504.00
-
EUR 252.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with FITC. |
AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), HRP |
4-PAL230Ra01-HRP |
Cloud-Clone |
-
EUR 423.60
-
EUR 4062.00
-
EUR 1128.00
-
EUR 541.20
-
EUR 266.40
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with HRP. |
AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), PE |
4-PAL230Ra01-PE |
Cloud-Clone |
-
EUR 396.00
-
EUR 3754.80
-
EUR 1046.40
-
EUR 504.00
-
EUR 252.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with PE. |
AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), APC-Cy7 |
4-PAL230Ra01-APC-Cy7 |
Cloud-Clone |
-
EUR 788.40
-
EUR 9184.80
-
EUR 2413.20
-
EUR 1058.40
-
EUR 426.00
|
- 100ul
- 10ml
- 1ml
- 200ul
- 20ul
|
|
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with APC-Cy7. |
Rabbit Anti-Human AXL (phosphoY821) IgG (aff pure) |
AB-23085-A |
Alpha Diagnostics |
100ug |
EUR 578.4 |
Rabbit Anti-Human AXL protein IgG, aff pure |
AXL12-A |
Alpha Diagnostics |
100 ul |
EUR 578.4 |
AXL (Phospho-Tyr703) Antibody |
13143-100ul |
SAB |
100ul |
EUR 302.4 |
AXL (Phospho-Tyr703) Antibody |
13143-50ul |
SAB |
50ul |
EUR 224.4 |
AXL (Phospho-Tyr702) Antibody |
12791-100ul |
SAB |
100ul |
EUR 302.4 |
AXL (Phospho-Tyr702) Antibody |
12791-50ul |
SAB |
50ul |
EUR 224.4 |
AXL (pY697) Blocking Peptide |
20-abx064128 |
Abbexa |
|
|
|
Human AXL shRNA Plasmid |
20-abx950384 |
Abbexa |
|
|
|
Phospho-AXL (Tyr703) Antibody |
AF7293 |
Affbiotech |
200ul |
EUR 540 |
Phospho-AXL (Tyr698) Antibody |
AF8522 |
Affbiotech |
200ul |
EUR 540 |
Phospho-AXL (Tyr702) Antibody |
AF8523 |
Affbiotech |
200ul |
EUR 540 |
Phospho-AXL (Tyr702) Antibody |
AF3824 |
Affbiotech |
100ul |
EUR 540 |
Phospho-AXL (Y691) Antibody |
1-CSB-PA030244 |
Cusabio |
|
|
|
Description: A polyclonal antibody against Phospho-AXL (Y691). Recognizes Phospho-AXL (Y691) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000 |
AXL Antibody, HRP conjugated |
1-CSB-PA326981LB01HU |
Cusabio |
|
|
|
Description: A polyclonal antibody against AXL. Recognizes AXL from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
AXL Antibody, FITC conjugated |
1-CSB-PA326981LC01HU |
Cusabio |
|
|
|
Description: A polyclonal antibody against AXL. Recognizes AXL from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
AXL Antibody, Biotin conjugated |
1-CSB-PA326981LD01HU |
Cusabio |
|
|
|
Description: A polyclonal antibody against AXL. Recognizes AXL from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
Human AXL ELISA Kit |
LF-EK50867 |
Abfrontier |
1×96T |
EUR 777.6 |
Recombinant Human Axl Protein |
RP00087 |
Abclonal |
5 μg |
EUR 163.2 |
AXL Kinase Assay Kit |
79711 |
BPS Bioscience |
96 rxns. |
EUR 535 |
Description: The AXL Kinase Assay Kit is designed to measure AXL kinase activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent. The AXL Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant AXL enzyme, AXL substrate, ATP and kinase assay buffer for 100 enzyme reactions |
Axl sgRNA CRISPR Lentivector (Mouse) (Target 1) |
K4394002 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Axl sgRNA CRISPR Lentivector (Mouse) (Target 2) |
K4394003 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Axl sgRNA CRISPR Lentivector (Mouse) (Target 3) |
K4394004 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Axl Protein Vector (Mouse) (pPB-C-His) |
PV157850 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPB-N-His) |
PV157851 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPM-C-HA) |
PV157852 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPM-C-His) |
PV157853 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPB-C-His) |
PV157854 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPB-N-His) |
PV157855 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPM-C-HA) |
PV157856 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPM-C-His) |
PV157857 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPB-C-His) |
PV157858 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPB-N-His) |
PV157859 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPM-C-HA) |
PV157860 |
ABM |
500 ng |
EUR 1278 |
Axl Protein Vector (Mouse) (pPM-C-His) |
PV157861 |
ABM |
500 ng |
EUR 1278 |
Axl (Phospho-Tyr691) Polyclonal Antibody |
12335-100ul |
SAB |
100ul |
EUR 302.4 |
Axl (Phospho-Tyr691) Polyclonal Antibody |
12335-50ul |
SAB |
50ul |
EUR 224.4 |
Axl (phospho Tyr691) Polyclonal Antibody |
ABP55771-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
Description: A polyclonal antibody for detection of Axl phospho Tyr691) from Human, Mouse, Rat. This Axl phospho Tyr691) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the phosphorylation site of Y691 |
Axl (phospho Tyr691) Polyclonal Antibody |
ABP55771-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
Description: A polyclonal antibody for detection of Axl phospho Tyr691) from Human, Mouse, Rat. This Axl phospho Tyr691) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the phosphorylation site of Y691 |
Axl (phospho Tyr691) Polyclonal Antibody |
ABP55771-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
Description: A polyclonal antibody for detection of Axl phospho Tyr691) from Human, Mouse, Rat. This Axl phospho Tyr691) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the phosphorylation site of Y691 |
We assume that this is actually a double oxidation mechanically different from the single oxidation is observed and that the high stress conditions support the oxidation mechanism of double (and double oxidation sensitive tryptophan residue) whereas the single oxidation appears to be the main mode of H2O2 oxidation under pressure and length of a term thermal stability and favors a different tryptophan residues are more prone to oxidation mechanism single.