Comparison of the ELISA and ECL Assay for Vedolizumab Anti-drug Antibodies: Assessing the Impact on Pharmacokinetics and Safety Outcomes of the Phase 3 GEMINI Trials

Vedolizumab immunogenicity was assessed using an enzyme-linked immunosorbent assay (ELISA) with ~ 0.5 ug / mL drug disorders, which may underestimate the on-drug immunogenicity. We aimed to compare the results between ELISA and immunogenicity of a new drug-tolerant electrochemiluminescence (ECL) assay (and two versions of neutralizing tests, drug-sensitive to the drug-tolerant).

ECL assay drug tolerance is ~ 100 times higher than the ELISA (≥ 50 mg / mL vs 0.5 ug / mL to 500 ng / mL positive control), and the sensitivity of the test is <5 ng / mL for both tests. Vedolizumab immunogenicity rated at 2000 GEMINI 1 and 2 patients initially tested by ELISA and retested by the ECL assay. anti-drug antibodies (ADA) results in infusion-related reactions-and pharmacokinetic (PK) was examined using descriptive statistics and population PK analysis.

With the ECL assay, 6% (86/1427) of patients treated with vedolizumab as induction and maintenance therapy ADA-positive tested. Of these, 20 patients with persistent positive and 56 had a neutralizing antibody. By ELISA, 4% (56/1434) of this ADA-positive patients, 9 were constantly positive, and 33 have antibodies. Among 61 patients with infusion-related reactions, 6 (10%) is ADA-positive (2 continuous positive) by ECL assay. By ELISA, 3 (5%) both ADA-positive patients and constantly positive.

Partial results (96%) was similar in both tests. In a population PK models are updated, ADA-positive status is expected to increase linearly vedolizumab clearance by a factor of 1.10 (95% credible interval 1.03 to 1.17), consistent with previous reports. ADA impacts the safety and PK modeling generally remained consistently good using ELISA or ECL assay.

Antitumor effect of humanized anti-tissue factor antibody-drug conjugate in a model of peritoneal disseminated pancreatic cancer

tissue factor (TF) is an attractive target for cancer therapy due to excess in some kinds of malignancies. Additionally, TF has been reported to play a functional role both in the development of cancer and metastasis. Several groups have developed antibody-drug conjugate (ADC) to the TF to be used as a cancer treatment, and has demonstrated efficacy in subcutaneous xenograft models of conventional and patient-derived xenograft model.

However, no previous studies have investigated the effectiveness of anti-TF ADC model with advanced cancer. This study developed the original anti-human TF monoclonal antibody conjugated to monomethyl auristatin E, and evaluated its efficacy in vivo in a xenograft model of pancreatic cancer with peritoneal dissemination. An in vitro study showed that the anti-TF ADC has a strong binding affinity and cytotoxic activity against human pancreatic cancer cells highly expressed TF antigen.

Anti-TF ADC also show greater antitumor effect than the ADC control in the conventional subcutaneous xenograft models, with efficacy depends on TF expression in the tumor tissue. Furthermore, the anti-TF ADC significantly inhibited tumor growth in an orthotopic xenograft model, and extend the lifespan in a murine model of peritoneal dissemination. These results suggest that anti-TF ADC has the potential to be an effective treatment not only for the primary tumor, but also for those who disseminated widely. Therefore, it can be concluded that the ADC targeting TF may be a promising agent for the treatment of advanced pancreatic cancer.

 

Treatment of Antibody-Mediated Rejection After Kidney Transplant: Effects immunology, clinical response, and histologic findings

BACKGROUND antibody-mediated rejection (AMR) prize with clinical manifestations are diverse and may have a potential negative impact on graft function and survival. If not treated successfully, AMR can lead to a 20-30% loss of the graft after one year. Little is known about the efficacy of the treatment of the AMR, and the most appropriate treatment strategy has not been determined.

This study evaluated the effects of AMR treatment with plasmapheresis (PP) and intravenous immunoglobulin (IVIG) on renal function, the intensity of anti-HLA antibodies, and graft biopsy morphology. MATERIALS AND METHODS retrospective cohort study of this center including AMR kidney transplant recipients with biopsy treated with PP and / or IVIG. clinical findings, mean fluorescence intensity of donor-specific antibodies anti-HLA (DSA), and graft histology findings, classified according to the Park scored at the time of AMR and 6 and 12 months later, were evaluated.

Results Of the 42 patients who met the inclusion criteria, 38 (90.5%) received IVIG and 26 (61.9%) underwent PP. At AMR diagnosis, 36 (85.7%) patients had proteinuria, with an estimated glomerular filtration rate they remained stable during follow-up. During the first year, 8 (19.0%) patients experienced graft failure, but did not die with a functioning graft. The decline of class I panel reactive antibodies were observed 6 and 12 months after treatment AMR, with a significant reduction in the DSA-A and -B fluorescence intensity, but there is no change in the DSA-DQ. Graft biopsy showed a reduction in inflammation and score C4D, without any improvement in microvascular inflammation. CONCLUSION AMR reduce treatment related biopsy and serological markers AMR, but does not affect the DSA-DQ.

Tryptophan Oxidation of Monoclonal Antibody under Various Conditions Oxidative Stress: Preparation oxidative Specific Favor Unlike tryptophan residue

oxidation of tryptophan could play an important role in choosing a therapeutic monoclonal antibody for commercialization. Monoclonal antibodies that harbor very sensitive tryptophan residue is usually discarded in favor of antibodies oxidation resistance.

Tryptophan residue individual susceptibility to oxidation is usually evaluated through the forced degradation studies during the development process of molecules. We compared the results of some general forced degradation „stress test” for any tryptophan residues in the monoclonal antibody and found that the oxidation state of high stress consistently give different ratings across the tryptophan residue oxidative sensitivity of individuals compared with long-term thermal stability or low stress conditions. We then determined that this difference in ranking is largely due to an overabundance of double oxidation (ie detected as 32 Da) specific tryptophan residue under high stress conditions as compared to a single oxidation (ie 16 Da).

anti-AXL (7E10)
LF-MA30273	Abfrontier	100 ul	EUR 583.2
Description: Mouse Monoclonal to AXL

anti- AXL antibody
FNab00754	FN Test	100µg	EUR 606.3
Description: Antibody raised against AXL

Anti-Axl antibody
STJ91791	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to Axl.

Anti-Axl antibody
STJ97643	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to Axl.

Anti-Axl antibody
STJ97856	St John's Laboratory	100 µl	EUR 280.8
Description: Mouse monoclonal to Axl.

Anti-Axl antibody
STJ97857	St John's Laboratory	100 µl	EUR 280.8
Description: Mouse monoclonal to Axl.

Anti-Axl Antibody
STJ500198	St John's Laboratory	100 µg	EUR 571.2

Anti-AXL antibody
STJ119885	St John's Laboratory	100 µl	EUR 332.4
Description: The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene.

Anti-AXL antibody
STJ22748	St John's Laboratory	100 µl	EUR 332.4
Description: The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene.

Anti-AXL (6C8)
YF-MA10084	Abfrontier	100 ug	EUR 435.6
Description: Mouse monoclonal to AXL

Anti-AXL (6G1)
YF-MA10085	Abfrontier	100 ug	EUR 435.6
Description: Mouse monoclonal to AXL

Anti-Axl (2C10)
YF-MA12092	Abfrontier	100 ug	EUR 435.6
Description: Mouse monoclonal to Axl

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN	ImmunoStep	50 µg	EUR 418.8

Anti-Axl Antibody BIOTIN
STJ500199	St John's Laboratory	100 µg	EUR 703.2

Anti-Axl Antibody FITC
STJ500200	St John's Laboratory	100 µg	EUR 703.2

Rabbit Anti-Mouse AXL protein IgG-Biotinylated
AXL11-BTN	Alpha Diagnostics	100 ul	EUR 634.8

Mouse AXL shRNA Plasmid
20-abx973661	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

Mouse AXL ELISA Kit
LF-EK50868	Abfrontier	1×96T	EUR 777.6

Polyclonal Rabbit Anti-AXL antibody
APR05486G	Leading Biology	0.1ml	EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Rabbit Anti-AXL . This antibody is tested and proven to work in the following applications:

Anti-Phospho-AXL-Y702 antibody
STJ11100989	St John's Laboratory	100 µl	EUR 471.6
Description: The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene.

Anti-Phospho-Axl (Y691) antibody
STJ90939	St John's Laboratory	200 µl	EUR 236.4
Description: Axl is a protein encoded by the AXL gene which is approximately 98,3 kDa. Axl is localised to the cell membrane. It is involved in the GPCR pathway, ERK signalling, actin nucleation by ARP-WASP complex and activation of cAMP-dependent PKA. This protein falls under the Tyro3-Axl-Mer receptor tyrosine kinase subfamily. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6. Axl is expressed in primary colon tumors but weakly expressed in normal colon tissue. Mutations in the AXL gene may result in lymphocytic choriomeningitis, femoral neuropathy and Borna disease. STJ90939 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Axl protein which only binds about Y691 when Y691 is phosphorylated.

Recombinant AXL Receptor Tyrosine Kinase (AXL)
4-RPL230Hu01	Cloud-Clone	EUR 569.44 EUR 276.00 EUR 1805.38 EUR 681.79 EUR 1243.58 EUR 456.00 EUR 4333.44	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human AXL Receptor Tyrosine Kinase expressed in: E.coli

Recombinant AXL Receptor Tyrosine Kinase (AXL)
4-RPL230Ra01	Cloud-Clone	EUR 614.59 EUR 288.00 EUR 1974.72 EUR 738.24 EUR 1356.48 EUR 487.20 EUR 4756.80	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat AXL Receptor Tyrosine Kinase expressed in: E.coli

AXL antibody
70R-51253	Fitzgerald	100 ul	EUR 344.4
Description: Purified Polyclonal AXL antibody

Axl Antibody
39365-100ul	SAB	100ul	EUR 468

AXL Antibody
48205-100ul	SAB	100ul	EUR 399.6

AXL Antibody
48205-50ul	SAB	50ul	EUR 286.8

AXL antibody
10R-1995	Fitzgerald	100 ul	EUR 392.4
Description: Mouse monoclonal AXL antibody

AXL antibody
10R-2051	Fitzgerald	100 ul	EUR 483.6
Description: Mouse monoclonal AXL antibody

AXL Antibody
ABF8412	Lifescience Market	100 ug	EUR 525.6

AXL siRNA
20-abx908739	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

AXL siRNA
20-abx908740	Abbexa	EUR 661.20 EUR 878.40	15 nmol 30 nmol

AXL antibody
70R-9655	Fitzgerald	50 ug	EUR 560.4
Description: Affinity purified rabbit polyclonal AXL antibody

AXL Antibody
AF6824	Affbiotech	100ul	EUR 420

AXL Antibody
AF7793	Affbiotech	200ul	EUR 540

AXL Antibody
AF8412	Affbiotech	200ul	EUR 540

AXL Antibody
BF0290	Affbiotech	200ul	EUR 540

AXL Antibody
1-CSB-PA030245	Cusabio	EUR 266.40 EUR 234.00	100ug 50ug
Description: A polyclonal antibody against AXL. Recognizes AXL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000

AXL Antibody
1-CSB-PA297707	Cusabio	EUR 266.40 EUR 234.00	100ug 50ug
Description: A polyclonal antibody against AXL. Recognizes AXL from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000

AXL Antibody
1-CSB-PA326981LA01HU	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against AXL. Recognizes AXL from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200

AXL Antibody
F50552-0.08ML	NSJ Bioreagents	0.08 ml	EUR 165

AXL Antibody
F50552-0.4ML	NSJ Bioreagents	0.4 ml	EUR 379

AXL Antibody
F50553-0.08ML	NSJ Bioreagents	0.08 ml	EUR 165

AXL Antibody
F50553-0.4ML	NSJ Bioreagents	0.4 ml	EUR 379

AXL Antibody
F50554-0.08ML	NSJ Bioreagents	0.08 ml	EUR 165

AXL Antibody
F50554-0.4ML	NSJ Bioreagents	0.4 ml	EUR 379

AXL Antibody
F53357-0.08ML	NSJ Bioreagents	0.08 ml	EUR 165

AXL Antibody
F53357-0.4ML	NSJ Bioreagents	0.4 ml	EUR 379

AXL Antibody
F44438-0.08ML	NSJ Bioreagents	0.08 ml	EUR 165

AXL Antibody
F44438-0.4ML	NSJ Bioreagents	0.4 ml	EUR 379

AXL Antibody
RQ6041	NSJ Bioreagents	100 ug	EUR 419
Description: Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene. This gene is mapped to 19q13.2. The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene.

Rabbit Anti-Mouse AXL protein IgG, aff pure
AXL11-A	Alpha Diagnostics	100 ul	EUR 578.4

Mouse Monoclonal Anti-Human AXL protein IgG-Biotinylated
AXL13-BTN	Alpha Diagnostics	100 ul	EUR 634.8

Polyclonal Goat anti-GST α-form
GST-ANTI-1	Detroit R&D	50 uL	EUR 336

Polyclonal Goat anti-GST μ-form
GST-ANTI-2	Detroit R&D	50 uL	EUR 336

Polyclonal Goat anti-GST p-form
GST-ANTI-3	Detroit R&D	50 uL	EUR 336

AXL ELISA Kit (Mouse) (OKBB00412)
OKBB00412	Aviva Systems Biology	96 Wells	EUR 606
Description: Description of target: Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene. The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation. This receptor can also mediate cell aggregation by homophilic binding. Axl is a chronic myelogenous leukemia-associated oncogene and also associated with colon cancer and melanoma. It is in close vicinity to the bcl3 oncogene, which is at 19q13.1-q13.2. The Axl gene is evolutionarily conserved between vertebrate species. This gene has two different alternatively spliced transcript variants.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL

Mouse AXL PicoKine ELISA Kit
EK0660	BosterBio	96 wells	EUR 510
Description: For quantitative detection of mouse AXL in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Axl ORF Vector (Mouse) (pORF)
ORF039463	ABM	1.0 ug DNA	EUR 607.2

Axl ORF Vector (Mouse) (pORF)
ORF039464	ABM	1.0 ug DNA	EUR 607.2

Axl ORF Vector (Mouse) (pORF)
ORF039465	ABM	1.0 ug DNA	EUR 607.2

ELISA kit for Mouse AXL
EK5264	SAB	96 tests	EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse AXL in samples from serum, plasma, tissue homogenates and other biological fluids.

Mouse Monoclonal Anti-Human AXL protein IgG, aff pure
AXL13-M	Alpha Diagnostics	100 ul	EUR 578.4

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat)
4-PAL230Ra01	Cloud-Clone	EUR 330.00 EUR 3549.60 EUR 872.40 EUR 420.00 EUR 271.20	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL)

Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
SEL230Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 6227.58
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human AXL Receptor Tyrosine Kinase (AXL) in serum, plasma, tissue homogenates and other biological fluids.

Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
SEL230Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 618.04
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human AXL Receptor Tyrosine Kinase (AXL) in serum, plasma, tissue homogenates and other biological fluids.

Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
SEL230Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 831.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human AXL Receptor Tyrosine Kinase (AXL) in serum, plasma, tissue homogenates and other biological fluids.

Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
SEL230Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 3381.66
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human AXL Receptor Tyrosine Kinase (AXL) in serum, plasma, tissue homogenates and other biological fluids.

Human AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
4-SEL230Hu	Cloud-Clone	EUR 6288.00 EUR 3322.80 EUR 831.60	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human AXL Receptor Tyrosine Kinase (AXL) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species.

Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
SEL230Ra-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 6745.94
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat AXL Receptor Tyrosine Kinase (AXL) in serum, plasma and other biological fluids.

Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
SEL230Ra-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 660.72
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat AXL Receptor Tyrosine Kinase (AXL) in serum, plasma and other biological fluids.

Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
SEL230Ra-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 892.46
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat AXL Receptor Tyrosine Kinase (AXL) in serum, plasma and other biological fluids.

Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
SEL230Ra-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 3656.09
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat AXL Receptor Tyrosine Kinase (AXL) in serum, plasma and other biological fluids.

Rat AXL Receptor Tyrosine Kinase (AXL) ELISA Kit
4-SEL230Ra	Cloud-Clone	EUR 6806.40 EUR 3596.40 EUR 892.80	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat AXL Receptor Tyrosine Kinase (AXL) in samples from Serum, plasma and other biological fluids. with no significant corss-reactivity with analogues from other species.

AXL Rabbit pAb
A0532-100ul	Abclonal	100 ul	EUR 369.6

AXL Rabbit pAb
A0532-200ul	Abclonal	200 ul	EUR 550.8

AXL Rabbit pAb
A0532-20ul	Abclonal	20 ul	Ask for price

AXL Rabbit pAb
A0532-50ul	Abclonal	50 ul	Ask for price

AXL antibody (Tyr691)
70R-32634	Fitzgerald	100 ug	EUR 392.4
Description: Rabbit polyclonal AXL antibody (Tyr691)

AXL Blocking Peptide
33R-7673	Fitzgerald	100 ug	EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of AXL antibody, catalog no. 70R-9655

Axl Recombinant Protein
11-290	ProSci	0.1 mg	EUR 651.3
Description: AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL contains two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. AXL is highly expressed in metastatic colon tumors. AXL is activated by GAS6-binding and subsequent autophosphorylation. AXL is involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation.

Axl Polyclonal Antibody
ABP55772-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y697

Axl Polyclonal Antibody
ABP55772-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y697

Axl Polyclonal Antibody
ABP55772-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y697

AXL (pY691) Antibody
abx148474-100ug	Abbexa	100 ug	EUR 526.8

AXL (pY702) Antibody
abx148475-100ug	Abbexa	100 ug	EUR 526.8

Axl Polyclonal Antibody
ABP57379-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y691

Axl Polyclonal Antibody
ABP57379-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y691

Axl Polyclonal Antibody
ABP57379-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of Axl from Human, Mouse, Rat. This Axl antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the non-phosphorylation site of Y691

AXL Blocking Peptide
20-abx061788	Abbexa	EUR 309.60 EUR 460.80	1 mg 5 mg

AXL (pT697) Antibody
20-abx009871	Abbexa	EUR 376.80 EUR 560.40 EUR 243.60	100 ul 200 ul 30 ul

AXL Rabbit pAb
A17874-100ul	Abclonal	100 ul	EUR 369.6

AXL Rabbit pAb
A17874-200ul	Abclonal	200 ul	EUR 550.8

AXL Rabbit pAb
A17874-20ul	Abclonal	20 ul	EUR 219.6

AXL Rabbit pAb
A17874-50ul	Abclonal	50 ul	EUR 267.6

AXL (pY691) Antibody
20-abx249424	Abbexa	EUR 376.80 EUR 117.60 EUR 477.60 EUR 594.00	100 ug 10 ug 200 ug 300 µg

AXL Recombinant Protein
96-037	ProSci	0.2 mg	EUR 588.3
Description: AXL Receptor Tyrosine Kinase is also known as Tyrosine-protein kinase receptor UFO, which belongs to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily. AXL contains two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. AXL is highly expressed in metastatic colon tumors. AXL is activated by GAS6-binding and subsequent autophosphorylation. AXL is involved in signal transduction from the extracellular matrix into the cytoplasm by binding growth factors, and thus implicated in the stimulation of cell proliferation.

Polyclonal AXL Antibody
APR05948G	Leading Biology	0.1ml	EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AXL . This antibody is tested and proven to work in the following applications:

AXL Blocking Peptide
AF7793-BP	Affbiotech	1mg	EUR 234

AXL Blocking Peptide
AF8412-BP	Affbiotech	1mg	EUR 234

AXL Blocking Peptide
BF0290-BP	Affbiotech	1mg	EUR 234

AXL Conjugated Antibody
C48205	SAB	100ul	EUR 476.4

AXL cloning plasmid
CSB-CL326981HU-10ug	Cusabio	10ug	EUR 1033.2
Description: A cloning plasmid for the AXL gene.

Axl Polyclonal Antibody
ES8372-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against Axl from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Axl Polyclonal Antibody
ES8372-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against Axl from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Axl Polyclonal Antibody
ES6771-100ul	ELK Biotech	100ul	EUR 334.8
Description: A Rabbit Polyclonal antibody against Axl from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

Axl Polyclonal Antibody
ES6771-50ul	ELK Biotech	50ul	EUR 248.4
Description: A Rabbit Polyclonal antibody against Axl from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

pDONR223-AXL Plasmid
PVTB00185S	Lifescience Market	2 ug	EUR 427.2

AXL, FLAG-Tag
100174	BPS Bioscience	10 µg	EUR 355
Description: Human AXL, also known as Tyrosine-protein kinase receptor UFO, and JTK11, GenBank Accession No. NM_021913, a.a. 473-894 (end) with N-terminal FLAG-Tag, MW= 49 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Axl, GST-tag
40180	BPS Bioscience	10 µg	EUR 355
Description: AXL (GenBank Accession No. NM_021913), a.a. 473-894 with N-terminal GST-tag, MW= 77 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Rabbit Anti-Human AXL protein IgG-Biotinylated
AXL12-BTN	Alpha Diagnostics	100 ul	EUR 634.8

Axl sgRNA CRISPR Lentivector set (Mouse)
K4394001	ABM	3 x 1.0 ug	EUR 406.8

Nori® Mouse Axl ELISA Kit
GR117424	Genorise Scientific	96-well	EUR 461

ELISA kit for Human AXL (AXL Receptor Tyrosine Kinase)
ELK7559	ELK Biotech	1 plate of 96 wells	EUR 518.4
Description: A sandwich ELISA kit for detection of AXL Receptor Tyrosine Kinase from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Rat AXL (AXL Receptor Tyrosine Kinase)
ELK8078	ELK Biotech	1 plate of 96 wells	EUR 518.4
Description: A sandwich ELISA kit for detection of AXL Receptor Tyrosine Kinase from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), APC
4-PAL230Ra01-APC	Cloud-Clone	EUR 465.60 EUR 4664.40 EUR 1278.00 EUR 601.20 EUR 284.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with APC.

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), Biotinylated
4-PAL230Ra01-Biotin	Cloud-Clone	EUR 411.60 EUR 3489.60 EUR 1006.80 EUR 510.00 EUR 278.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with Biotin.

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), Cy3
4-PAL230Ra01-Cy3	Cloud-Clone	EUR 571.20 EUR 6169.20 EUR 1654.80 EUR 751.20 EUR 330.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with Cy3.

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), FITC
4-PAL230Ra01-FITC	Cloud-Clone	EUR 396.00 EUR 3754.80 EUR 1046.40 EUR 504.00 EUR 252.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with FITC.

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), HRP
4-PAL230Ra01-HRP	Cloud-Clone	EUR 423.60 EUR 4062.00 EUR 1128.00 EUR 541.20 EUR 266.40	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with HRP.

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), PE
4-PAL230Ra01-PE	Cloud-Clone	EUR 396.00 EUR 3754.80 EUR 1046.40 EUR 504.00 EUR 252.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with PE.

AXL Receptor Tyrosine Kinase (AXL) Polyclonal Antibody (Rat), APC-Cy7
4-PAL230Ra01-APC-Cy7	Cloud-Clone	EUR 788.40 EUR 9184.80 EUR 2413.20 EUR 1058.40 EUR 426.00	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Rat AXL Receptor Tyrosine Kinase (AXL). This antibody is labeled with APC-Cy7.

Rabbit Anti-Human AXL (phosphoY821) IgG (aff pure)
AB-23085-A	Alpha Diagnostics	100ug	EUR 578.4

Rabbit Anti-Human AXL protein IgG, aff pure
AXL12-A	Alpha Diagnostics	100 ul	EUR 578.4

AXL (Phospho-Tyr703) Antibody
13143-100ul	SAB	100ul	EUR 302.4

AXL (Phospho-Tyr703) Antibody
13143-50ul	SAB	50ul	EUR 224.4

AXL (Phospho-Tyr702) Antibody
12791-100ul	SAB	100ul	EUR 302.4

AXL (Phospho-Tyr702) Antibody
12791-50ul	SAB	50ul	EUR 224.4

AXL (pY697) Blocking Peptide
20-abx064128	Abbexa	EUR 376.80 EUR 610.80	1 mg 5 mg

AXL (Phospho- Tyr691) Antibody
ABF8522	Lifescience Market	100 ug	EUR 525.6

AXL (Phospho- Tyr702) Antibody
ABF8523	Lifescience Market	100 ug	EUR 525.6

Human AXL (phosphoY821) peptide
AB-23085-P	Alpha Diagnostics	100ug	EUR 196.8

Human AXL shRNA Plasmid
20-abx950384	Abbexa	EUR 961.20 EUR 1345.20	150 µg 300 µg

Phospho-AXL (Tyr703) Antibody
AF7293	Affbiotech	200ul	EUR 540

Phospho-AXL (Tyr698) Antibody
AF8522	Affbiotech	200ul	EUR 540

Phospho-AXL (Tyr702) Antibody
AF8523	Affbiotech	200ul	EUR 540

Phospho-AXL (Tyr702) Antibody
AF3824	Affbiotech	100ul	EUR 540

Phospho-AXL (Y691) Antibody
1-CSB-PA030244	Cusabio	EUR 266.40 EUR 234.00	100ug 50ug
Description: A polyclonal antibody against Phospho-AXL (Y691). Recognizes Phospho-AXL (Y691) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000

AXL Antibody, HRP conjugated
1-CSB-PA326981LB01HU	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against AXL. Recognizes AXL from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

AXL Antibody, FITC conjugated
1-CSB-PA326981LC01HU	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against AXL. Recognizes AXL from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

AXL Antibody, Biotin conjugated
1-CSB-PA326981LD01HU	Cusabio	EUR 380.40 EUR 402.00	100ug 50ug
Description: A polyclonal antibody against AXL. Recognizes AXL from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

AXL ELISA KIT|Human
EF008027	Lifescience Market	96 Tests	EUR 826.8

Human AXL ELISA Kit
LF-EK50867	Abfrontier	1×96T	EUR 777.6

Recombinant Human Axl Protein
RP00087	Abclonal	5 μg	EUR 163.2

pCMV-SPORT6-AXL Plasmid
PVT16334	Lifescience Market	2 ug	EUR 390

AXL Kinase Assay Kit
79711	BPS Bioscience	96 rxns.	EUR 535
Description: The AXL Kinase Assay Kit is designed to measure AXL kinase activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent. The AXL Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant AXL enzyme, AXL substrate, ATP and kinase assay buffer for 100 enzyme reactions

Axl sgRNA CRISPR Lentivector (Mouse) (Target 1)
K4394002	ABM	1.0 ug DNA	EUR 184.8

Axl sgRNA CRISPR Lentivector (Mouse) (Target 2)
K4394003	ABM	1.0 ug DNA	EUR 184.8

Axl sgRNA CRISPR Lentivector (Mouse) (Target 3)
K4394004	ABM	1.0 ug DNA	EUR 184.8

Axl Protein Vector (Mouse) (pPB-C-His)
PV157850	ABM	500 ng	EUR 1278

Axl Protein Vector (Mouse) (pPB-N-His)
PV157851	ABM	500 ng	EUR 1278

Axl Protein Vector (Mouse) (pPM-C-HA)
PV157852	ABM	500 ng	EUR 1278

Axl Protein Vector (Mouse) (pPM-C-His)
PV157853	ABM	500 ng	EUR 1278

Axl Protein Vector (Mouse) (pPB-C-His)
PV157854	ABM	500 ng	EUR 1278

Axl Protein Vector (Mouse) (pPB-N-His)
PV157855	ABM	500 ng	EUR 1278

Axl Protein Vector (Mouse) (pPM-C-HA)
PV157856	ABM	500 ng	EUR 1278

Axl Protein Vector (Mouse) (pPM-C-His)
PV157857	ABM	500 ng	EUR 1278

Axl Protein Vector (Mouse) (pPB-C-His)
PV157858	ABM	500 ng	EUR 1278

Axl Protein Vector (Mouse) (pPB-N-His)
PV157859	ABM	500 ng	EUR 1278

Axl Protein Vector (Mouse) (pPM-C-HA)
PV157860	ABM	500 ng	EUR 1278

Axl Protein Vector (Mouse) (pPM-C-His)
PV157861	ABM	500 ng	EUR 1278

Axl (Phospho-Tyr691) Polyclonal Antibody
12335-100ul	SAB	100ul	EUR 302.4

Axl (Phospho-Tyr691) Polyclonal Antibody
12335-50ul	SAB	50ul	EUR 224.4

Axl (phospho Tyr691) Polyclonal Antibody
ABP55771-003ml	Abbkine	0.03ml	EUR 189.6
Description: A polyclonal antibody for detection of Axl phospho Tyr691) from Human, Mouse, Rat. This Axl phospho Tyr691) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the phosphorylation site of Y691

Axl (phospho Tyr691) Polyclonal Antibody
ABP55771-01ml	Abbkine	0.1ml	EUR 346.8
Description: A polyclonal antibody for detection of Axl phospho Tyr691) from Human, Mouse, Rat. This Axl phospho Tyr691) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the phosphorylation site of Y691

Axl (phospho Tyr691) Polyclonal Antibody
ABP55771-02ml	Abbkine	0.2ml	EUR 496.8
Description: A polyclonal antibody for detection of Axl phospho Tyr691) from Human, Mouse, Rat. This Axl phospho Tyr691) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Axl around the phosphorylation site of Y691

We assume that this is actually a double oxidation mechanically different from the single oxidation is observed and that the high stress conditions support the oxidation mechanism of double (and double oxidation sensitive tryptophan residue) whereas the single oxidation appears to be the main mode of H2O2 oxidation under pressure and length of a term thermal stability and favors a different tryptophan residues are more prone to oxidation mechanism single.